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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAALPRDk42GSuof7i1B7L463K-Ml0uciV9f06m8cN0yck#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAALPRDk42GSuof7i1B7L463K-Ml0uciV9f06m8cN0yck#_4 http://www.w3.org/ns/prov#value Ang II also induces ROS in glomerular mesangial (23) and tubular epithelial (12) cells. Ang II-induced ROS in vascular smooth muscle cells were shown to be derived from NADPH oxidase (24). ROS induce AGE (18) and upregulate TGF-1 (4,8), both of which, in turn, induce ROS generation in mesangial cells, high glucose-induced PKC activation in mesangial cells is effectively blocked by antioxidants vitamin E, N-acetyl cysteine (NAC), and taurine, suggesting that ROS mediate high glucose-induced PKC activation. http://www.tkuhn.ch/bel2nanopub/RAALPRDk42GSuof7i1B7L463K-Ml0uciV9f06m8cN0yck#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12874439 http://www.tkuhn.ch/bel2nanopub/RAALPRDk42GSuof7i1B7L463K-Ml0uciV9f06m8cN0yck#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAALPRDk42GSuof7i1B7L463K-Ml0uciV9f06m8cN0yck#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12874439 http://www.tkuhn.ch/bel2nanopub/RAALPRDk42GSuof7i1B7L463K-Ml0uciV9f06m8cN0yck#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAALPRDk42GSuof7i1B7L463K-Ml0uciV9f06m8cN0yck#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAALPRDk42GSuof7i1B7L463K-Ml0uciV9f06m8cN0yck#_4 http://www.tkuhn.ch/bel2nanopub/RAALPRDk42GSuof7i1B7L463K-Ml0uciV9f06m8cN0yck#pubinfo http://www.tkuhn.ch/bel2nanopub/RAALPRDk42GSuof7i1B7L463K-Ml0uciV9f06m8cN0yck http://purl.org/dc/terms/created 2014-07-03T14:32:04.946+02:00 http://www.tkuhn.ch/bel2nanopub/RAALPRDk42GSuof7i1B7L463K-Ml0uciV9f06m8cN0yck http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAALPRDk42GSuof7i1B7L463K-Ml0uciV9f06m8cN0yck http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234