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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAAJGouPVkkLbHvivP8YPSB6aiCujM5cQdlvMZ9gye0NY#_6 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAAJGouPVkkLbHvivP8YPSB6aiCujM5cQdlvMZ9gye0NY#_5 http://www.w3.org/ns/prov#value We identified an interaction between Smad5 and suppressor of variegation 3-9 homolog 2 (Suv39h2), a chromatin modifier enzyme. Suv39h proteins are histone methyltransferases that methylate histone H3 on lysine 9, resulting in transcriptional repression or silencing of target genes.... Biochemical studies in mammalian cells demonstrated that Smad5 binds to both known mammalian isoforms of Suv39h proteins, and that Smad proteins activated by the TGF-beta signaling pathway, Smad2 and Smad3, do not bind with significant affinity. http://www.tkuhn.ch/bel2nanopub/RAAJGouPVkkLbHvivP8YPSB6aiCujM5cQdlvMZ9gye0NY#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15107829 http://www.tkuhn.ch/bel2nanopub/RAAJGouPVkkLbHvivP8YPSB6aiCujM5cQdlvMZ9gye0NY#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAAJGouPVkkLbHvivP8YPSB6aiCujM5cQdlvMZ9gye0NY#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15107829 http://www.tkuhn.ch/bel2nanopub/RAAJGouPVkkLbHvivP8YPSB6aiCujM5cQdlvMZ9gye0NY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAAJGouPVkkLbHvivP8YPSB6aiCujM5cQdlvMZ9gye0NY#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAAJGouPVkkLbHvivP8YPSB6aiCujM5cQdlvMZ9gye0NY#_5 http://www.tkuhn.ch/bel2nanopub/RAAJGouPVkkLbHvivP8YPSB6aiCujM5cQdlvMZ9gye0NY#pubinfo http://www.tkuhn.ch/bel2nanopub/RAAJGouPVkkLbHvivP8YPSB6aiCujM5cQdlvMZ9gye0NY http://purl.org/dc/terms/created 2014-07-03T14:30:22.822+02:00 http://www.tkuhn.ch/bel2nanopub/RAAJGouPVkkLbHvivP8YPSB6aiCujM5cQdlvMZ9gye0NY http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAAJGouPVkkLbHvivP8YPSB6aiCujM5cQdlvMZ9gye0NY http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234