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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAAJ5Rdb418_s2_N15Ca6QiNEFi7YeFWg_bTyP3BWLQXo#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAAJ5Rdb418_s2_N15Ca6QiNEFi7YeFWg_bTyP3BWLQXo#_3 http://www.w3.org/ns/prov#value Inhibition of complex I activity was not specific for dopamine, since noradrenaline, a less reactive catecholamine [54], the dopamine precursor and metabolite l-3,4-dihydroxy-phenylalanine (l-DOPA) and 3,4-dihydroxyphenylacetic acid (DOPAC), respectively, as well as the specific toxin for catecholaminergic neurons, 6-hydroxydopamine (6-OHDA), all inhibited the enzyme, although not as efficiently as dopamine. Interestingly, the bi-catechol nordihydroguaiaretic acid (NDGA) also inhibited NADH dehydrogenase activity, while triethylamine and ethylamine had no effect. 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