@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAAIUkM4cC0IPkzVmQCVqo7dA-D7dYtNZSqHspMHJ_I_M> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAAIUkM4cC0IPkzVmQCVqo7dA-D7dYtNZSqHspMHJ_I_M#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix hasPart: <http://purl.obolibrary.org/obo/BFO_0000051> .
@prefix ProteinComplex: <http://amigo.geneontology.org/amigo/term/GO:0043234> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 hasPart: sub:_2, sub:_3;
    a ProteinComplex: .
  
  sub:_2 geneProductOf: hgnc:7669;
    a Protein: .
  
  sub:_3 geneProductOf: hgnc:6996;
    a Protein: .
  
  sub:_4 hasAgent: sub:_5;
    a go:0042789 .
  
  sub:_5 geneProductOf: hgnc:6996;
    a Protein: .
  
  sub:_6 occursIn: species:9606;
    rdf:object sub:_4;
    rdf:predicate belv:directlyIncreases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "complex(p(HGNC:NCOA2),p(HGNC:MEF2C)) => tscript(p(HGNC:MEF2C))" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_8;
    pav:version "20131211" .
  
  sub:_7 prov:value "# Ariadne: Apparently all D- type cyclins can block MEF2 activity as cotransfection of cyclin D1, D2, or D3  together with cdk4 blocked the ability of exogenous MEF2C to activate  expression of the MEF2x3LUC reporter in 10T1/2 cells (Fig. 1 C, cf. lane 2 with  lanes 3,4,5). [Regulation] # Ariadne: In  addition, because it is known that GRIP-1 can rapidly exchange in and out of  the punctate nuclear structures when bound to steroid hormone receptors ( Schaufele et al. 2000 ), it seems possible that the GRIP-1-MEF2 complex may  similarly diffuse in and out of these structures. [Binding] Prior work has indicated that D-type cyclin-cdk4 complexes, which are only active in proliferating cells, can suppress the skeletal muscle differentiation program in proliferating myoblasts. We have found that cyclin D-cdk activity blocks the association of MEF2C with the coactivator protein GRIP-1 and thereby inhibits the activity of MEF2. Our findings indicate that cyclin D-cdk4 activity represses skeletal muscle differentiation in proliferating cells by blocking the association of MEF2 with the coactivator GRIP-1 and concomitantly disrupts the association of these factors with punctate nuclear subdomains within the cell.";
    prov:wasQuotedFrom pubmed:12130539 .
  
  sub:_8 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:12130539;
    prov:wasDerivedFrom beldoc:, sub:_7 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:31:51.689+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}