@prefix this: <http://www.tkuhn.ch/bel2nanopub/RAAFvr0hyN7JJMIFaeY3LfzrZ4499hgqTLhM4q7cvPe6k> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RAAFvr0hyN7JJMIFaeY3LfzrZ4499hgqTLhM4q7cvPe6k#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix scomp: <http://resource.belframework.org/belframework/20131211/namespace/selventa-named-complexes/> .
@prefix ProteinComplex: <http://amigo.geneontology.org/amigo/term/GO:0043234> .
@prefix hasAgent: <http://semanticscience.org/resource/SIO_000139> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  scomp:p85%2Fp110%20PI3Kinase%20Complex a ProteinComplex: .
  
  sub:_1 hasAgent: scomp:p85%2Fp110%20PI3Kinase%20Complex;
    a go:0016301 .
  
  sub:_2 occursIn: species:9606;
    rdf:object go:0016477;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "kin(complex(SCOMP:\"p85/p110 PI3Kinase Complex\")) -> bp(GOBP:\"cell migration\")" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_4;
    pav:version "20131211" .
  
  sub:_3 prov:value "NF-?B transcriptional activity can be also regulated independently of I? B degradation by the direct phosphorylation of NF-?B subunits. The phosphorylation of NF-?B was demonstrated with I?B kinases [47, 48], protein kinase CK2 (formerly casein kinase II) [49, 50], protein kinase A (PKA) [51], phosphatidylinositol 3-kinase (PI3K) [52, 53] and protein kinase C? (PKC?) [53, 54]. In addition, mitogen-activated protein (MAP) kinase regulated the activity of NF-? B independently of the NF-? B phosphorylation [55]. Summary: NFKB1 (MIM 164011 ) or NFKB2 (MIM 164012 ) is bound to REL (MIM 164910 ), RELA (MIM 164014 ), or RELB (MIM 604758 ) to form the NFKB complex. The NFKB complex is inhibited by I-kappa-B proteins (NFKBIA, MIM 164008 , or NFKBIB, MIM 604495 ), which inactivate NF-kappa-B by trapping it in the cytoplasm. Phosphorylation of serine residues on the I-kappa-B proteins by kinases (IKBKA, MIM 600664 , or IKBKB) marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B complex. Activated NFKB complex translocates into the nucleus and binds DNA at kappa-B-binding motifs such as 5-prime GGGRNNYYCC 3-prime or 5-prime HGGARNYYCC 3-prime (where H is A, C, or T; R is an A or G purine; and Y is a C or T pyrimidine).[supplied by OMIM] The induction of cell motility has been linked to the activation of PI 3-kinase [57], and a significant increase of PI-3 kinase activity was detected in highly invasive MDA-MB-231 cells over that observed in MCF-7 cells [58]. However, the motility of breast cancer cells MDA-MB-231 was suppressed by the overexpression of dominant negative regulatory (p85?) subunit, as well as by the inhibition of catalytic (p110) subunit by specific inhibitors of p110, wortmannin and LY294002 [58].";
    prov:wasQuotedFrom pubmed:15180498 .
  
  sub:_4 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:15180498;
    prov:wasDerivedFrom beldoc:, sub:_3 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:32:22.143+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}