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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAAE_fD0jNvqAOV_FhQ9a8odxMnx7LBaaIjD0HxNHiIQQ#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAAE_fD0jNvqAOV_FhQ9a8odxMnx7LBaaIjD0HxNHiIQQ#_3 http://www.w3.org/ns/prov#value Human microvascular endothelial cells from lung (HMVEC-Lung, HMVEC-L) and cardiac (HMVEC-Cardiac, HMVEC-C) cells were cultured and exposed to hypoxia (1% O2, 5% CO2, and 94% N2) on 6 separate occasions, and total RNA was extracted. Experimental samples (n = 3) were formed by randomly pooling RNA from 2 independent experiments. This process was repeated at each of 4 experimental time points yielding 12 separate arrays for lung and cardiac experiments. Affymetrix GeneChip Human Genome U133A chips, which allow the simultaneous analysis of 22,283 gene transcripts, were used. * Genstruct R-pipeline analysis of GSE11341 conducted Nov 2010 by DD. Cutoffs for curation applied by AV were FC>1.5 and adj. p<.01. The 48h treatment timepoint was selected for curation because, as the paper reports, \"An incremental increase in the expression of 2 well-characterized hypoxia-responsive marker genes, namely VEGF-A and solute carrier family 2 member 1 [SLC2A1 (previously called GLUT1)], was measured by RT-PCR.\" http://www.tkuhn.ch/bel2nanopub/RAAE_fD0jNvqAOV_FhQ9a8odxMnx7LBaaIjD0HxNHiIQQ#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/18469115 http://www.tkuhn.ch/bel2nanopub/RAAE_fD0jNvqAOV_FhQ9a8odxMnx7LBaaIjD0HxNHiIQQ#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAAE_fD0jNvqAOV_FhQ9a8odxMnx7LBaaIjD0HxNHiIQQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/18469115 http://www.tkuhn.ch/bel2nanopub/RAAE_fD0jNvqAOV_FhQ9a8odxMnx7LBaaIjD0HxNHiIQQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAAE_fD0jNvqAOV_FhQ9a8odxMnx7LBaaIjD0HxNHiIQQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAAE_fD0jNvqAOV_FhQ9a8odxMnx7LBaaIjD0HxNHiIQQ#_3 http://www.tkuhn.ch/bel2nanopub/RAAE_fD0jNvqAOV_FhQ9a8odxMnx7LBaaIjD0HxNHiIQQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAAE_fD0jNvqAOV_FhQ9a8odxMnx7LBaaIjD0HxNHiIQQ http://purl.org/dc/terms/created 2014-07-03T14:33:21.273+02:00 http://www.tkuhn.ch/bel2nanopub/RAAE_fD0jNvqAOV_FhQ9a8odxMnx7LBaaIjD0HxNHiIQQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAAE_fD0jNvqAOV_FhQ9a8odxMnx7LBaaIjD0HxNHiIQQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234