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bp(GO:"response to hypoxia") -> complex(p(HGNC:APAF1),p(EGID:54205),p(HGNC:CASP9))
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Approximately 61,000 statements.
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Copyright (c) 2011-2012, Selventa. All rights reserved.
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BEL Framework Large Corpus Document
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binding of ligands such as FASL and TNF to FAS and the TNF receptor, respectively, induces the formation of the death-induced signalling complex (DISC) DISC in turn recruits CASP8 and promotes the cascade of procaspase activation that follows hypoxia and DNA damage induce a series of biochemical events that result in the permeabilization of the outer mitochondrial membrane, the release of cytochrome c and other pro-apoptotic molecules, the formation of the apoptosome, a large complex that contains cytochrome c, apoptotic protease activating factor 1 and caspase 9, and caspase activation
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Selventa
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2014-07-03T14:30:26.244+02:00
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