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[The variant C allele of rs5743836 causes greater TLR9 transcriptional activity compared to the T allele, therefore, higher TLR9 activity may be related to efficient removal of microbial pathogens within the endometrium. Clearly, the association of these TLR9 polymorphisms and endometrial cancer risk must be further examined in an independent population. The results point towards the importance of examining immune response in endometrial tumourigenesis to understand new pathways that may be implicated in disease.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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