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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAA7-sPHm7G9R2KgF81LvvmjOWeVsksjlfnM0AdUy7zRQ#_7 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAA7-sPHm7G9R2KgF81LvvmjOWeVsksjlfnM0AdUy7zRQ#_6 http://www.w3.org/ns/prov#value ere, we show that all three of the ubiquitously expressed JAKs--JAK1, JAK2, and Tyk2--become phosphorylated on tyrosine in both mouse BALB/c 3T3 cells and human fibroblasts engineered to express the PDGF-beta receptor. All three proteins are also associated with the activated receptor. Through the use of cell lines each lacking an individual JAK, we find that in contrast to interferon signaling, PDGF-induced JAK phosphorylation and activation of STAT1 and STAT3 is independent of the presence of any other single JAK but does require receptor tyrosine kinase activity. http://www.tkuhn.ch/bel2nanopub/RAA7-sPHm7G9R2KgF81LvvmjOWeVsksjlfnM0AdUy7zRQ#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/8657151 http://www.tkuhn.ch/bel2nanopub/RAA7-sPHm7G9R2KgF81LvvmjOWeVsksjlfnM0AdUy7zRQ#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAA7-sPHm7G9R2KgF81LvvmjOWeVsksjlfnM0AdUy7zRQ#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/8657151 http://www.tkuhn.ch/bel2nanopub/RAA7-sPHm7G9R2KgF81LvvmjOWeVsksjlfnM0AdUy7zRQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAA7-sPHm7G9R2KgF81LvvmjOWeVsksjlfnM0AdUy7zRQ#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAA7-sPHm7G9R2KgF81LvvmjOWeVsksjlfnM0AdUy7zRQ#_6 http://www.tkuhn.ch/bel2nanopub/RAA7-sPHm7G9R2KgF81LvvmjOWeVsksjlfnM0AdUy7zRQ#pubinfo http://www.tkuhn.ch/bel2nanopub/RAA7-sPHm7G9R2KgF81LvvmjOWeVsksjlfnM0AdUy7zRQ http://purl.org/dc/terms/created 2014-07-03T14:30:57.432+02:00 http://www.tkuhn.ch/bel2nanopub/RAA7-sPHm7G9R2KgF81LvvmjOWeVsksjlfnM0AdUy7zRQ http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAA7-sPHm7G9R2KgF81LvvmjOWeVsksjlfnM0AdUy7zRQ http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234