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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAA1F7vemB9HnLUsYM0Otmmy0ZKsDu1QADQw0AlsJVRsc#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RAA1F7vemB9HnLUsYM0Otmmy0ZKsDu1QADQw0AlsJVRsc#_3 http://www.w3.org/ns/prov#value TNF-alpha mediates insulin resistance via serine phosphorylation of insulin receptor substrate (IRS-1) in skeletal muscle, which inhibits the ability of insulin to stimulate GLUT-4 translocation to the cell membrane and therefore reduces glucose uptake (43). Conversely, inhibition of TNF-alpha results in increased insulin-stimulated IRS-1 tyrosine phosphorylation (10, 43). The ability of TNF-alpha to serine phosphorylate IRS-1 may be mediated via diacylglycerol (DAG). Incubating intact rat skeletal muscle strips with TNF-alpha significantly increased palmitate incorporation into DAG (7). This is important because DAGs are known activators of conventional and novel protein kinase C isoforms that serine phosphorylate, and thus inhibit, IRS-1. http://www.tkuhn.ch/bel2nanopub/RAA1F7vemB9HnLUsYM0Otmmy0ZKsDu1QADQw0AlsJVRsc#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16020439 http://www.tkuhn.ch/bel2nanopub/RAA1F7vemB9HnLUsYM0Otmmy0ZKsDu1QADQw0AlsJVRsc#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAA1F7vemB9HnLUsYM0Otmmy0ZKsDu1QADQw0AlsJVRsc#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16020439 http://www.tkuhn.ch/bel2nanopub/RAA1F7vemB9HnLUsYM0Otmmy0ZKsDu1QADQw0AlsJVRsc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAA1F7vemB9HnLUsYM0Otmmy0ZKsDu1QADQw0AlsJVRsc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAA1F7vemB9HnLUsYM0Otmmy0ZKsDu1QADQw0AlsJVRsc#_3 http://www.tkuhn.ch/bel2nanopub/RAA1F7vemB9HnLUsYM0Otmmy0ZKsDu1QADQw0AlsJVRsc#pubinfo http://www.tkuhn.ch/bel2nanopub/RAA1F7vemB9HnLUsYM0Otmmy0ZKsDu1QADQw0AlsJVRsc http://purl.org/dc/terms/created 2014-07-03T14:32:47.581+02:00 http://www.tkuhn.ch/bel2nanopub/RAA1F7vemB9HnLUsYM0Otmmy0ZKsDu1QADQw0AlsJVRsc http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAA1F7vemB9HnLUsYM0Otmmy0ZKsDu1QADQw0AlsJVRsc http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234