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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#_5 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#_4 http://www.w3.org/ns/prov#value N6,O2'-dibutyrylcyclo-3',5'-AMP injected to intact rats alone or in combination with theophylline increases the activity of guanidine acetate methyltransferase (GAMT) in liver and pancreas. Cyclic 3',5'-AMP and its dibutyryl analog administered immediately or two hours after the suturing of common bile duct (SCBD) stimulate the increase of pancreatic GAMT activity 2-3 fold. Glucagon, injected intraabdominally simultaneously with SCBD and administration of theophylline, dramatically increases the theophylline effect on the GAMT activity. The freezing of rat pancreas pretreated witn secretin, a hormone structurally similar to glucagon, results in a 1.5-2-fold increase of creatine synthesis from S-adenosylmethionine and guanidinacetic acid. An hour after glucagon administration to intact rats the GAMT activity of liver increases 9 times. The effect of glucagon is enhanced by insulin. Cycloheximide inhibits the increase of GAMT activity, induced by glucagon or a combination of glucagon and insulin. Experiments on tissue homogenates demonstrate that 3',5'-AMP in concentrations of 10(-8) --10(-2) M does not affect the GAMT activity or to some extent inhibits the enzyme. The homogenate incubation in a medium containing 10(-5) M epinephrine or 10(-7) M caffeine and 5 mM Mg2+ leads to an increase in the GAMT activity. Oligomycin removes the stimulating effects of caffeine and Mg2+ on the enzyme activation. This is probably due to the presence of 3',5'-AMP-dependent protein kinase in the mechanism of GAMT activation by cyclic AMP. http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/179611 http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/179611 http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#_4 http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#pubinfo http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI http://purl.org/dc/terms/created 2014-07-03T14:30:52.170+02:00 http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234