[ { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#pubinfo" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#Head" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#_1", "@type" : [ "http://amigo.geneontology.org/amigo/term/GO:0003824" ], "http://semanticscience.org/resource/SIO_000139" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#_2" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#_2", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.informatics.jax.org/marker/MGI:1098221" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#_3", "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ], "http://purl.obolibrary.org/obo/BFO_0000066" : [ { "@id" : "http://purl.bioontology.org/ontology/MSH/D008099" }, { "@id" : "http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#_1" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ { "@id" : "http://www.selventa.com/vocabulary/increases" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ { "@id" : "http://resource.belframework.org/belframework/1.0/namespace/selventa-legacy-chemical-names/cyclic%20AMP" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#assertion", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "a(SCHEM:\"cyclic AMP\") -> cat(p(MGI:Gamt))" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#assertion" }, { "@graph" : [ { "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel", "http://purl.org/dc/elements/1.1/description" : [ { "@value" : "Approximately 61,000 statements." } ], "http://purl.org/dc/elements/1.1/rights" : [ { "@value" : "Copyright (c) 2011-2012, Selventa. All rights reserved." } ], "http://purl.org/dc/elements/1.1/title" : [ { "@value" : "BEL Framework Large Corpus Document" } ], "http://purl.org/pav/authoredBy" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#_5" } ], "http://purl.org/pav/version" : [ { "@value" : "1.4" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#_4", "http://www.w3.org/ns/prov#value" : [ { "@value" : "N6,O2'-dibutyrylcyclo-3',5'-AMP injected to intact rats alone or in combination with theophylline increases the activity of guanidine acetate methyltransferase (GAMT) in liver and pancreas. Cyclic 3',5'-AMP and its dibutyryl analog administered immediately or two hours after the suturing of common bile duct (SCBD) stimulate the increase of pancreatic GAMT activity 2-3 fold. Glucagon, injected intraabdominally simultaneously with SCBD and administration of theophylline, dramatically increases the theophylline effect on the GAMT activity. The freezing of rat pancreas pretreated witn secretin, a hormone structurally similar to glucagon, results in a 1.5-2-fold increase of creatine synthesis from S-adenosylmethionine and guanidinacetic acid. An hour after glucagon administration to intact rats the GAMT activity of liver increases 9 times. The effect of glucagon is enhanced by insulin. Cycloheximide inhibits the increase of GAMT activity, induced by glucagon or a combination of glucagon and insulin. Experiments on tissue homogenates demonstrate that 3',5'-AMP in concentrations of 10(-8) --10(-2) M does not affect the GAMT activity or to some extent inhibits the enzyme. The homogenate incubation in a medium containing 10(-5) M epinephrine or 10(-7) M caffeine and 5 mM Mg2+ leads to an increase in the GAMT activity. Oligomycin removes the stimulating effects of caffeine and Mg2+ on the enzyme activation. This is probably due to the presence of 3',5'-AMP-dependent protein kinase in the mechanism of GAMT activation by cyclic AMP." } ], "http://www.w3.org/ns/prov#wasQuotedFrom" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/179611" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#_5", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "Selventa" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#assertion", "http://www.w3.org/ns/prov#hadPrimarySource" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/179611" } ], "http://www.w3.org/ns/prov#wasDerivedFrom" : [ { "@id" : "http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel" }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#_4" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#provenance" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI", "http://purl.org/dc/terms/created" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2014-07-03T14:30:52.170+02:00" } ], "http://purl.org/pav/createdBy" : [ { "@id" : "http://orcid.org/0000-0001-6818-334X" }, { "@id" : "http://orcid.org/0000-0002-1267-0234" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RAA-SY8JpjZbB8f8djv8bf4WKV1GodrqRzpTwlZBxHrVI#pubinfo" } ]