http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#Head http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10 http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#assertion http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10 http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#provenance http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10 http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#pubinfo http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#assertion http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.informatics.jax.org/marker/MGI:1098228 http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CL_0000312 http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090 http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#_1 http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://resource.belframework.org/belframework/20131211/namespace/selventa-legacy-chemicals/Tetradecanoylphorbol%20acetate http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#assertion http://www.w3.org/2000/01/rdf-schema#label a(SCHEM:"Tetradecanoylphorbol acetate") -> r(MGI:Alox8) http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#_3 http://www.w3.org/ns/prov#value In this study, we found TPA-induced 8S-LOX mRNA expression is a result of increased transcription in SSIN primary keratinocytes and further investigated transcriptional regulation of 8S-LOX expression by cloning its promoter.We then identified a Sp1 binding site located -77 to -68 from the ATG that is a TPA-responsive element (TRE) of the promoter and that Sp1, Sp2, and Sp3 proteins bind to the TRE.We also found that the binding of these proteins to the TRE was significantly increased by TPA treatment and inhibition of the binding by mithramycin A decreased TPA-induced promoter activity as well as 8S-LOX mRNA expression. These data suggest that increased binding of Sp1, Sp2, and Sp3 to the TRE of the 8S-LOX promoter is a mechanism by which TPA induces 8S-LOX expression in keratinocytes.induced 8S-LOX mRNA expression is a result of increased transcription in SSIN primary keratinocytes and further investigated transcriptional regulation of 8S-LOX expression by cloning its promoter. http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/14711820 http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/14711820 http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#_3 http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10#pubinfo http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10 http://purl.org/dc/terms/created 2014-07-03T14:32:14.265+02:00 http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA9zBHozenKSjoGmnLVQrKhMJC9uR0fXam2K_tb8xnK10 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234