http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8130_head http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8 http://www.nanopub.org/nschema#hasAssertion http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8130_assertion http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8 http://www.nanopub.org/nschema#hasProvenance http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8130_provenance http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8 http://www.nanopub.org/nschema#hasPublicationInfo http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8130_publicationInfo http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8130_assertion http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Assertion http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8130_provenance http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Provenance http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8130_publicationInfo http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#PublicationInfo http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8130_assertion http://identifiers.org/ncbigene/23657 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C16612 http://linkedlifedata.com/resource/umls/id/C3825627 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://ncicb.nci.nih.gov/xml/owl/EVS/Thesaurus.owl#C7057 http://rdf.disgenet.org/resource/gda/DGN73460582de2bb8fbe9df449850eb7504 http://semanticscience.org/resource/SIO_000628 http://identifiers.org/ncbigene/23657 http://rdf.disgenet.org/resource/gda/DGN73460582de2bb8fbe9df449850eb7504 http://semanticscience.org/resource/SIO_000628 http://linkedlifedata.com/resource/umls/id/C3825627 http://rdf.disgenet.org/resource/gda/DGN73460582de2bb8fbe9df449850eb7504 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://semanticscience.org/resource/SIO_001123 http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8130_provenance http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8130_assertion http://purl.org/dc/terms/description [Overall, C3A cells responded to cysteine deprivation by activation of the eukaryotic initiation factor (eIF)2alpha kinase-mediated integrated stress response to inhibit global protein synthesis; increased expression of genes containing amino acid response elements (ASNS, ATF3, CEBPB, SLC7A11, and TRIB3); increased expression of genes for amino acid transporters (SLC7A11, SLC1A4, and SLC3A2), aminoacyl-tRNA synthetases (CARS), and, to a limited extent, amino acid metabolism (ASNS and CTH); increased expression of genes that act to suppress growth (STC2, FOXO3A, GADD45A, LNK, and INHBE); and increased expression of several enzymes that favor glutathione synthesis and maintenance of protein thiol groups (GCLC, GCLM, SLC7A11, and TXNRD1).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine. http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8130_assertion http://purl.org/ontology/wi/core#evidence http://rdf.disgenet.org/v3.0.0/void/source_evidence_literature http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8130_assertion http://semanticscience.org/resource/SIO_000772 http://identifiers.org/pubmed/18285520 http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8130_assertion http://www.w3.org/ns/prov#wasDerivedFrom http://rdf.disgenet.org/v3.0.0/void/befree-20150227 http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8130_assertion http://www.w3.org/ns/prov#wasGeneratedBy http://purl.obolibrary.org/obo/ECO_0000203 http://rdf.disgenet.org/v3.0.0/void/befree-20150227 http://purl.org/pav/importedOn 2015-02-27 http://rdf.disgenet.org/v3.0.0/void/source_evidence_literature http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://purl.obolibrary.org/obo/ECO_0000212 http://rdf.disgenet.org/v3.0.0/void/source_evidence_literature http://www.w3.org/2000/01/rdf-schema#comment Gene-disease associations inferred from text-mining the literature. http://rdf.disgenet.org/v3.0.0/void/source_evidence_literature http://www.w3.org/2000/01/rdf-schema#label DisGeNET evidence - LITERATURE http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8130_publicationInfo http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8 http://purl.org/dc/terms/created 2015-08-25T14:46:34+02:00 http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8 http://purl.org/dc/terms/rights http://opendatacommons.org/licenses/odbl/1.0/ http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8 http://purl.org/dc/terms/rightsHolder http://rdf.disgenet.org/v3.0.0/void/IBIGroup http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8 http://purl.org/dc/terms/subject http://semanticscience.org/resource/SIO_000983 http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8 http://purl.org/net/provenance/ns#usedData http://rdf.disgenet.org/v3.0.0/void/disgenetv3.0rdf http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8 http://purl.org/pav/authoredBy http://orcid.org/0000-0001-5999-6269 http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8 http://purl.org/pav/authoredBy http://orcid.org/0000-0002-7534-7661 http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8 http://purl.org/pav/authoredBy http://orcid.org/0000-0002-9383-528X http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8 http://purl.org/pav/authoredBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8 http://purl.org/pav/authoredBy http://orcid.org/0000-0003-1244-7654 http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8 http://purl.org/pav/createdBy http://orcid.org/0000-0003-0169-8159 http://rdf.disgenet.org/resource/nanopub/NP876823.RA9sENgHM4h2lf7-s999FqLvCRZCUIUj61hB6hOPa3rc8 http://purl.org/pav/version v3.0.0.0 http://rdf.disgenet.org/v3.0.0/void/disgenetv3.0rdf http://purl.org/pav/version v3.0.0