sub:assertion {
d:DB00363 dv:ddi-interactor-in dr:DB00363_DB00382 .
d:DB00382 dv:ddi-interactor-in dr:DB00363_DB00382 .
dr:DB00363_DB00382 dct:identifier "drugbank_resource:DB00363_DB00382" ;
dct:title "DDI between Clozapine and Tacrine - The therapeutic effects of the central acetylcholinesterase inhibitor (AChEI), Tacrine, and/or the anticholinergic/antipsychotic, Clozapine, may be reduced due to antagonism. This interaction may be beneficial when the anticholinergic action is a side effect. AChEIs may also augment the central neurotoxic effect of antipsychotics. Monitor for extrapyramidal symptoms and decreased efficacy of both agents."@en ;
a dv:Drug-Drug-Interaction ;
rdfs:label "DDI between Clozapine and Tacrine - The therapeutic effects of the central acetylcholinesterase inhibitor (AChEI), Tacrine, and/or the anticholinergic/antipsychotic, Clozapine, may be reduced due to antagonism. This interaction may be beneficial when the anticholinergic action is a side effect. AChEIs may also augment the central neurotoxic effect of antipsychotics. Monitor for extrapyramidal symptoms and decreased efficacy of both agents. [drugbank_resource:DB00363_DB00382]"@en .
}