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[As compared to vector control Caco-2 cells, both oncogene-transfected cells exhibited: 1) a loss of response to insulin's stimulatory effect on mitogen-activated protein (MAP) kinase activity and cell proliferation, both of which were constitutively increased; 2) a decrease in insulin receptor (IR) affinity and insulin-stimulated exogenous tyrosine kinase activity, which resulted from increased protein kinase C (PKC) activity (Delage, S., Chastre, E., Empereur, S., Wicek, D., VeissiƩre, D., Capeau, J., Gespach, C., and Cherqui, G. (1993) Cancer Res.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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