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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA9dbP1vNYYGQdOO-1Xx_A8nQFME4Q39LvyVboEqG26pI#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA9dbP1vNYYGQdOO-1Xx_A8nQFME4Q39LvyVboEqG26pI#_4 http://www.w3.org/ns/prov#value We recently coined CST6 as a novel candidate tumor suppressor gene for breast cancer. CST6 indeed is expressed in the normal human breast epithelium, but little or not at all in breast carcinomas and breast cancer cell lines. Moreover, ectopic expression of CST6 in human breast cancer cells suppressed cell proliferation, migration, invasion, and orthotopic tumor growth. To obtain insights into the molecular mechanism by which CST6 exhibits its pleiotropic effects on tumor cells, we compared global gene expression profiles in mock- and CST6-transfected human MDA-MB-435S cells. Out of 12,625 transcript species, 61 showed altered expression. These included genes for extracellular matrix components, cytokines, kinases, and phosphatases, as well as several key transcription factors. TaqMan PCR assays were used to confirm the microarray data for 7 out of 11 genes. One down-regulated gene product, secreted autotaxin/lyso-phospholipase D, was of particular interest because its down-regulation by CST6 could explain most of CST6's effect on the breast cancer cells. This study thus provides the first evidence that CST6 plays a role in the modulation of genes, particularly, genes that are highly relevant to breast cancer progression. http://www.tkuhn.ch/bel2nanopub/RA9dbP1vNYYGQdOO-1Xx_A8nQFME4Q39LvyVboEqG26pI#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16356477 http://www.tkuhn.ch/bel2nanopub/RA9dbP1vNYYGQdOO-1Xx_A8nQFME4Q39LvyVboEqG26pI#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA9dbP1vNYYGQdOO-1Xx_A8nQFME4Q39LvyVboEqG26pI#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16356477 http://www.tkuhn.ch/bel2nanopub/RA9dbP1vNYYGQdOO-1Xx_A8nQFME4Q39LvyVboEqG26pI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA9dbP1vNYYGQdOO-1Xx_A8nQFME4Q39LvyVboEqG26pI#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA9dbP1vNYYGQdOO-1Xx_A8nQFME4Q39LvyVboEqG26pI#_4 http://www.tkuhn.ch/bel2nanopub/RA9dbP1vNYYGQdOO-1Xx_A8nQFME4Q39LvyVboEqG26pI#pubinfo http://www.tkuhn.ch/bel2nanopub/RA9dbP1vNYYGQdOO-1Xx_A8nQFME4Q39LvyVboEqG26pI http://purl.org/dc/terms/created 2014-07-03T14:32:53.636+02:00 http://www.tkuhn.ch/bel2nanopub/RA9dbP1vNYYGQdOO-1Xx_A8nQFME4Q39LvyVboEqG26pI http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA9dbP1vNYYGQdOO-1Xx_A8nQFME4Q39LvyVboEqG26pI http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234