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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA9Zym5La1Wg97a1fl7E69r9qpP__exEfWiS5yfz2USmM#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA9Zym5La1Wg97a1fl7E69r9qpP__exEfWiS5yfz2USmM#_4 http://www.w3.org/ns/prov#value Because the XBP1 promoter carries a perfect ER stress-response element, namely, the cis-acting element responsible for the induction of ER chaperones, and XBP1 mRNA is induced in response to ER stress with a time course similar to that of ER chaperone mRNAs, it is conjectured that transcription factor ATF6, activated immediately upon ER stress, induces the transcription of not only ER chaperone genes but also of XBP1 gene, such that pXBP1(S) produced by the splicing of an increased level of XBP1 mRNA escapes from proteasome-mediated degradation. http://www.tkuhn.ch/bel2nanopub/RA9Zym5La1Wg97a1fl7E69r9qpP__exEfWiS5yfz2USmM#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17110785 http://www.tkuhn.ch/bel2nanopub/RA9Zym5La1Wg97a1fl7E69r9qpP__exEfWiS5yfz2USmM#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA9Zym5La1Wg97a1fl7E69r9qpP__exEfWiS5yfz2USmM#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17110785 http://www.tkuhn.ch/bel2nanopub/RA9Zym5La1Wg97a1fl7E69r9qpP__exEfWiS5yfz2USmM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA9Zym5La1Wg97a1fl7E69r9qpP__exEfWiS5yfz2USmM#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA9Zym5La1Wg97a1fl7E69r9qpP__exEfWiS5yfz2USmM#_4 http://www.tkuhn.ch/bel2nanopub/RA9Zym5La1Wg97a1fl7E69r9qpP__exEfWiS5yfz2USmM#pubinfo http://www.tkuhn.ch/bel2nanopub/RA9Zym5La1Wg97a1fl7E69r9qpP__exEfWiS5yfz2USmM http://purl.org/dc/terms/created 2014-07-03T14:33:06.845+02:00 http://www.tkuhn.ch/bel2nanopub/RA9Zym5La1Wg97a1fl7E69r9qpP__exEfWiS5yfz2USmM http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA9Zym5La1Wg97a1fl7E69r9qpP__exEfWiS5yfz2USmM http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234