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L. Different Signaling Via Homodimeric and Heterodimeric Receptor Complexes Homodimeric alpha alpha - and beta beta -receptor complexes give overlapping but distinctly different effects on target cells (Table 2), which can be explained by differential interactions with various SH2 domain proteins (Table 4). The finding that PDGF-AB gives stronger mitogenic and chemotactic effects on cells expressing both alpha - and beta -receptors (179, 401) suggests that the heterodimeric alpha beta -receptor complex may have unique properties.
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