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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA92XMyHE1H39eJNBk0ch3L6c0k0h9ivzS7rKWUu4gz50#_3 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA92XMyHE1H39eJNBk0ch3L6c0k0h9ivzS7rKWUu4gz50#_2 http://www.w3.org/ns/prov#value Selected cells were pretreated with cytochalasin D (CD) or lactrunculin A (LA), agents that disrupt actin polymerization. Pretreatment of cells with CD or LA led to a significant inhibition of IRAK phosphorylation, and NF-kappaB nuclear translocation and activation. Endotoxin-induced actin polymerization is essential for optimal intracellular signaling through IRAK and NF-kappaB. 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