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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA914IQXqm78VMeiFGR6CKgYVECOyQ5ty7q64VERFlcF0#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA914IQXqm78VMeiFGR6CKgYVECOyQ5ty7q64VERFlcF0#_3 http://www.w3.org/ns/prov#value We injected a monoclonal antibody directed against the SH3 domain of Ras-GAP (mAb200) that has been shown to block Ras-GAP downstream signalling into various human normal and tumour cell lines. When mAb200 was microinjected into lung carcinoma H460 cells, cervix carcinoma HeLa cells and colon carcinoma HCT116 cells, massive cell death occurred. Breast carcinoma SKBR3 cells, non small lung H322 and colon HT29 carcinoma cells were also sensitive to the mAb200 antibody, although to a lesser extent (data not shown). http://www.tkuhn.ch/bel2nanopub/RA914IQXqm78VMeiFGR6CKgYVECOyQ5ty7q64VERFlcF0#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/10490822 http://www.tkuhn.ch/bel2nanopub/RA914IQXqm78VMeiFGR6CKgYVECOyQ5ty7q64VERFlcF0#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA914IQXqm78VMeiFGR6CKgYVECOyQ5ty7q64VERFlcF0#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/10490822 http://www.tkuhn.ch/bel2nanopub/RA914IQXqm78VMeiFGR6CKgYVECOyQ5ty7q64VERFlcF0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA914IQXqm78VMeiFGR6CKgYVECOyQ5ty7q64VERFlcF0#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA914IQXqm78VMeiFGR6CKgYVECOyQ5ty7q64VERFlcF0#_3 http://www.tkuhn.ch/bel2nanopub/RA914IQXqm78VMeiFGR6CKgYVECOyQ5ty7q64VERFlcF0#pubinfo http://www.tkuhn.ch/bel2nanopub/RA914IQXqm78VMeiFGR6CKgYVECOyQ5ty7q64VERFlcF0 http://purl.org/dc/terms/created 2014-07-03T14:31:31.965+02:00 http://www.tkuhn.ch/bel2nanopub/RA914IQXqm78VMeiFGR6CKgYVECOyQ5ty7q64VERFlcF0 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA914IQXqm78VMeiFGR6CKgYVECOyQ5ty7q64VERFlcF0 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234