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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#_4 http://www.w3.org/ns/prov#value Apolipoprotein J/clusterin is an enigmatic protein highly regulated in inflammation, apoptosis, and cancer. Despite extensive studies, its biological function has remained obscure. Here we show that apolipoprotein J inhibits neuroblastoma cell invasion. Since this function can be regulated by NF-kappaB, we explored the possibility that apolipoprotein J might interfere with NF-kappaB signaling. Ectopic apolipoprotein J expression strongly inhibited NF-kappaB activity in human neuroblastoma cells and murine embryonic fibroblasts by stabilizing inhibitors of NF-kappaB (IkappaBs). Steady state levels of IkappaB proteins are drastically reduced in mouse embryo fibroblasts after disruption of the apolipoprotein J gene. Absence of apolipoprotein J causes reduction of IkappaB stability, a tumor necrosis factor-dependent increase in NF-kappaB activity, increased transcription of the NF-kappaB target gene c-IAP and down-modulation of p53 protein. These results suggest that an unexpected physiological role of apolipoprotein J is to inhibit NF-kappaB signaling through stabilization of IkappaBs and that this activity may result in suppression of tumor cell motility. http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12882985 http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12882985 http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#_4 http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#pubinfo http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs http://purl.org/dc/terms/created 2014-07-03T14:32:05.230+02:00 http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234