[ { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs", "@type" : [ "http://www.nanopub.org/nschema#Nanopublication" ], "http://www.nanopub.org/nschema#hasAssertion" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#assertion" } ], "http://www.nanopub.org/nschema#hasProvenance" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#provenance" } ], "http://www.nanopub.org/nschema#hasPublicationInfo" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#pubinfo" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#Head" }, { "@graph" : [ { "@id" : "http://resource.belframework.org/belframework/20131211/namespace/selventa-named-complexes/Nfkb%20Complex", "@type" : [ "http://amigo.geneontology.org/amigo/term/GO:0043234" ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#_1", "@type" : [ "http://amigo.geneontology.org/amigo/term/GO:0042789" ], "http://semanticscience.org/resource/SIO_000139" : [ { "@id" : "http://resource.belframework.org/belframework/20131211/namespace/selventa-named-complexes/Nfkb%20Complex" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#_2", "@type" : [ "http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697" ], "http://purl.obolibrary.org/obo/RO_0002204" : [ { "@id" : "http://www.informatics.jax.org/marker/MGI:1197007" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#_3", "@type" : [ "http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement" ], "http://purl.obolibrary.org/obo/BFO_0000066" : [ { "@id" : "http://purl.obolibrary.org/obo/EFO_0004037" }, { "@id" : "http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=10090" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#object" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#_2" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate" : [ { "@id" : "http://www.selventa.com/vocabulary/increases" } ], "http://www.w3.org/1999/02/22-rdf-syntax-ns#subject" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#_1" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#assertion", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "tscript(complex(SCOMP:\"Nfkb Complex\")) -> r(MGI:Birc3)" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#assertion" }, { "@graph" : [ { "@id" : "http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel", "http://purl.org/dc/elements/1.1/description" : [ { "@value" : "Approximately 61,000 statements." } ], "http://purl.org/dc/elements/1.1/rights" : [ { "@value" : "Copyright (c) 2011-2012, Selventa. All rights reserved." } ], "http://purl.org/dc/elements/1.1/title" : [ { "@value" : "BEL Framework Large Corpus Document" } ], "http://purl.org/pav/authoredBy" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#_5" } ], "http://purl.org/pav/version" : [ { "@value" : "20131211" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#_4", "http://www.w3.org/ns/prov#value" : [ { "@value" : "Apolipoprotein J/clusterin is an enigmatic protein highly regulated in inflammation, apoptosis, and cancer. Despite extensive studies, its biological function has remained obscure. Here we show that apolipoprotein J inhibits neuroblastoma cell invasion. Since this function can be regulated by NF-kappaB, we explored the possibility that apolipoprotein J might interfere with NF-kappaB signaling. Ectopic apolipoprotein J expression strongly inhibited NF-kappaB activity in human neuroblastoma cells and murine embryonic fibroblasts by stabilizing inhibitors of NF-kappaB (IkappaBs). Steady state levels of IkappaB proteins are drastically reduced in mouse embryo fibroblasts after disruption of the apolipoprotein J gene. Absence of apolipoprotein J causes reduction of IkappaB stability, a tumor necrosis factor-dependent increase in NF-kappaB activity, increased transcription of the NF-kappaB target gene c-IAP and down-modulation of p53 protein. These results suggest that an unexpected physiological role of apolipoprotein J is to inhibit NF-kappaB signaling through stabilization of IkappaBs and that this activity may result in suppression of tumor cell motility." } ], "http://www.w3.org/ns/prov#wasQuotedFrom" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/12882985" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#_5", "http://www.w3.org/2000/01/rdf-schema#label" : [ { "@value" : "Selventa" } ] }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#assertion", "http://www.w3.org/ns/prov#hadPrimarySource" : [ { "@id" : "http://www.ncbi.nlm.nih.gov/pubmed/12882985" } ], "http://www.w3.org/ns/prov#wasDerivedFrom" : [ { "@id" : "http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel" }, { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#_4" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#provenance" }, { "@graph" : [ { "@id" : "http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs", "http://purl.org/dc/terms/created" : [ { "@type" : "http://www.w3.org/2001/XMLSchema#dateTime", "@value" : "2014-07-03T14:32:05.230+02:00" } ], "http://purl.org/pav/createdBy" : [ { "@id" : "http://orcid.org/0000-0001-6818-334X" }, { "@id" : "http://orcid.org/0000-0002-1267-0234" } ] } ], "@id" : "http://www.tkuhn.ch/bel2nanopub/RA8tnFBP_xgF0vlP0N6KqqqkbOp7kcrXcHbzCr-vLPlNs#pubinfo" } ]