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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA8qhrAAryfgyX0zoJFNlIVJMhF70sexHjIS74vsDc22A#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA8qhrAAryfgyX0zoJFNlIVJMhF70sexHjIS74vsDc22A#_3 http://www.w3.org/ns/prov#value STZ-diabetic rats transfected with AAVCMVT19NRhoA had a reduction in RhoA/Rho-kinase and MYPT-1 phosphorylation at a time when cavernosal eNOS protein, constitutive NOS activity, and cGMP levels were restored to levels found in the control rats. There was a significant decrease in erectile response to cavernosal nerve stimulation in the STZ-diabetic rat. AAVT19NRhoA gene transfer improved erectile responses in the STZ-diabetic rat to values similar to control. These data demonstrate a previously undescribed mechanism for the down-regulation of penile eNOS in diabetes mediated by activation of the RhoA/Rho-kinase pathway. Importantly, these data imply that inhibition of RhoA/Rho-kinase improves eNOS protein content and activity thus restoring erectile function in diabetes. http://www.tkuhn.ch/bel2nanopub/RA8qhrAAryfgyX0zoJFNlIVJMhF70sexHjIS74vsDc22A#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/15184671 http://www.tkuhn.ch/bel2nanopub/RA8qhrAAryfgyX0zoJFNlIVJMhF70sexHjIS74vsDc22A#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA8qhrAAryfgyX0zoJFNlIVJMhF70sexHjIS74vsDc22A#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/15184671 http://www.tkuhn.ch/bel2nanopub/RA8qhrAAryfgyX0zoJFNlIVJMhF70sexHjIS74vsDc22A#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA8qhrAAryfgyX0zoJFNlIVJMhF70sexHjIS74vsDc22A#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA8qhrAAryfgyX0zoJFNlIVJMhF70sexHjIS74vsDc22A#_3 http://www.tkuhn.ch/bel2nanopub/RA8qhrAAryfgyX0zoJFNlIVJMhF70sexHjIS74vsDc22A#pubinfo http://www.tkuhn.ch/bel2nanopub/RA8qhrAAryfgyX0zoJFNlIVJMhF70sexHjIS74vsDc22A http://purl.org/dc/terms/created 2014-07-03T14:32:22.264+02:00 http://www.tkuhn.ch/bel2nanopub/RA8qhrAAryfgyX0zoJFNlIVJMhF70sexHjIS74vsDc22A http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA8qhrAAryfgyX0zoJFNlIVJMhF70sexHjIS74vsDc22A http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234