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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA8nVv4Ok7zFa1Q9g6nu3vHTgqicFmcnbPh10OO_0mw-E#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA8nVv4Ok7zFa1Q9g6nu3vHTgqicFmcnbPh10OO_0mw-E#_4 http://www.w3.org/ns/prov#value To test our hypothesis that the Wnt/beta -catenin pathway is chronically activated in Foxl1 mutant mice we used indirect immunofluorescence to determine nuclear localization of beta -catenin as an indicator of the activated state of the Wnt pathway. Overall beta -catenin levels observed at low magnification, which mainly reflect beta -catenin contained in the adherens junctions, were comparable in the stomach of wild type and Foxl1 mutant mice (Fig. 2, A and C). However, at higher magnification we found a dramatic change in the subcellular localization of beta -catenin (Fig. 2, B and D). Foxl1 mutant mice had a larger number of nuclei with beta -catenin staining, indicating that the Wnt/beta -catenin pathway had indeed been activated in these cells. A similar increase in nuclear beta -catenin staining was also seen in the jejunum of Foxl1 mutant mice, confirming the correlation between increased proliferation and increased nuclear localization of beta -catenin (data not shown). To quantify the observed increase in nuclear beta -catenin, we performed Western blot analysis on cytoplasmic and nuclear extracts from Foxl1 mutant mice and their littermate controls (Fig. 3A). We found a significant increase in nuclear beta -catenin in the stomach and jejunum (2- and 2.3-fold, respectively) of Foxl1 mutant mice (Fig. 3B) confirming the immunofluorescence results, while cytoplasmic beta -catenin was unchanged. http://www.tkuhn.ch/bel2nanopub/RA8nVv4Ok7zFa1Q9g6nu3vHTgqicFmcnbPh10OO_0mw-E#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11555641 http://www.tkuhn.ch/bel2nanopub/RA8nVv4Ok7zFa1Q9g6nu3vHTgqicFmcnbPh10OO_0mw-E#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA8nVv4Ok7zFa1Q9g6nu3vHTgqicFmcnbPh10OO_0mw-E#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11555641 http://www.tkuhn.ch/bel2nanopub/RA8nVv4Ok7zFa1Q9g6nu3vHTgqicFmcnbPh10OO_0mw-E#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA8nVv4Ok7zFa1Q9g6nu3vHTgqicFmcnbPh10OO_0mw-E#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA8nVv4Ok7zFa1Q9g6nu3vHTgqicFmcnbPh10OO_0mw-E#_4 http://www.tkuhn.ch/bel2nanopub/RA8nVv4Ok7zFa1Q9g6nu3vHTgqicFmcnbPh10OO_0mw-E#pubinfo http://www.tkuhn.ch/bel2nanopub/RA8nVv4Ok7zFa1Q9g6nu3vHTgqicFmcnbPh10OO_0mw-E http://purl.org/dc/terms/created 2014-07-03T14:31:43.567+02:00 http://www.tkuhn.ch/bel2nanopub/RA8nVv4Ok7zFa1Q9g6nu3vHTgqicFmcnbPh10OO_0mw-E http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA8nVv4Ok7zFa1Q9g6nu3vHTgqicFmcnbPh10OO_0mw-E http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234