. . . . . . . . . . . . . . . . "tscript(p(HGNC:CTCF)) =| r(HGNC:PAX6)" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "These findings suggest that the capability of CTCF to suppress PAX6 transcription is dependent on its ability to bind to its binding motifs in the 80-bp region upstream from the PAX6 P0 promoter.To determine the dependence of CTCF DNA binding on these five CCCTC binding motifs in the 80-bp region upstream from the PAX6 P0 promoter, each of these motifs mutated from CCCTC to GGATC and was tested in EMSA binding and competing experiments. multiple mutations of CTCF-binding motifs in different combinations in the 80-bp sequence markedly decreased CTCF binding activity in nuclear extracts and CTCF binding activity with mutant probes was competitively inhibited by the respective multimutated cold probes (Figs. 5G 5H) . These results suggest that five potential CTCF-binding motifs in the 80-bp region are all involved in CTCF DNA binding." . . "Selventa" . . . . "2014-07-03T14:33:00.741+02:00"^^ . . .