sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements." ;
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved." ;
    dce:title "BEL Framework Large Corpus Document" ;
    pav:authoredBy sub:_6 ;
    pav:version "20131211" .
  sub:_5 prov:value "These findings suggest that the capability of CTCF to suppress PAX6 transcription is dependent on its ability to bind to its binding motifs in the 80-bp region upstream from the PAX6 P0 promoter.To determine the dependence of CTCF DNA binding on these five CCCTC binding motifs in the 80-bp region upstream from the PAX6 P0 promoter, each of these motifs mutated from CCCTC to GGATC and was tested in EMSA binding and competing experiments. multiple mutations of CTCF-binding motifs in different combinations in the 80-bp sequence markedly decreased CTCF binding activity in nuclear extracts and CTCF binding activity with mutant probes was competitively inhibited by the respective multimutated cold probes (Figs. 5G 5H) . These results suggest that five potential CTCF-binding motifs in the 80-bp region are all involved in CTCF DNA binding." ;
    prov:wasQuotedFrom pubmed:16723452 .
  sub:_6 rdfs:label "Selventa" .
  sub:assertion prov:hadPrimarySource pubmed:16723452 ;
    prov:wasDerivedFrom beldoc: , sub:_5 .
}