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http://semanticscience.org/resource/SIO_000139
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http://disease-ontology.org/term/DOID:1936
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a(SCHEM:cytokine) -> kin(p(SFAM:"MAPK JNK Family"))
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Approximately 61,000 statements.
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Copyright (c) 2011-2012, Selventa. All rights reserved.
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BEL Framework Large Corpus Document
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The 3 members of the JNK group of serine/threonine kinases, JNK-1, -2, and -3, JNK has recently emerged as a central metabolic regulator, playing an important role in the development of insulin resistance in obesity In response to stimuli such as ER stress, cytokines, and fatty acids, JNK is activated, whereupon it associates with and phosphorylates IRS-1 on Ser307, impairing insulin action
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Selventa
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2014-07-03T14:32:44.374+02:00
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