http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#Head http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#assertion http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#provenance http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#pubinfo http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#assertion http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#_1 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=1100 http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#_2 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#_1 http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.ebi.ac.uk/chebi/searchId.do?chebiId=27881 http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#assertion http://www.w3.org/2000/01/rdf-schema#label a(CHEBI:resveratrol) -> r(HGNC:BRCA1) http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#provenance http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#_4 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#_3 http://www.w3.org/ns/prov#value The phytochemical resveratrol, found in grapes, berries and peanuts, has been found to possess cancer chemopreventive effects by inhibiting diverse cellular events associated with tumour initiation, promotion and progression. Resveratrol is also a phyto-oestrogen, binds to and activates oestrogen receptors that regulate the transcription of oestrogen-responsive target genes such as the breast cancer susceptibility genes BRCA1 and BRCA2. We investigated the effects of resveratrol on BRCA1 and BRCA2 expression in human breast cancer cell lines (MCF7, HBL 100 and MDA-MB 231) using quantitative real-time RT-PCR, and by perfusion chromatography of the proteins. All cell lines were treated with 30 microM resveratrol. The expressions of BRCA1 and BRCA2 mRNAs were increased although no change in the expression of the proteins were found. These data indicate that resveratrol at 30 micro M can increase expression of genes involved in the aggressiveness of human breast tumour cell lines. http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12838319 http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12838319 http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#_3 http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc#pubinfo http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc http://purl.org/dc/terms/created 2014-07-03T14:30:14.143+02:00 http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA8fVAK7yRZTeu0XtZVoYVa8KSOFDqKJflWeNUDZkEwKc http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234