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[Regeneration of cortisol by 11?-hydroxysteroid dehydrogenase type 1 (11?-HSD1) within liver and adipose tissue may be of pathophysiological importance in obesity and the metabolic syndrome. single nucleotide polymorphisms (SNPs) in HSD11B1, the gene encoding 11?-HSD1, have been associated with type 2 diabetes and hypertension in population-based cohort studies, and with hyperandrogenism in patients with the polycystic ovary syndrome (PCOS).]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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