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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA8OcOmZnzN91C0z30hQUwI1efokqRH2vEY8rsGcU7tbA#_4 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA8OcOmZnzN91C0z30hQUwI1efokqRH2vEY8rsGcU7tbA#_3 http://www.w3.org/ns/prov#value To gain insight into the mechanisms underlying phytosterol actions, we conducted a proteomic study in the intestinal mucosa of phytosterol-fed apolipoprotein E-deficient hypercholesterolemic (apoE-/-) mice. Four of these proteins were selected for further study since they showed the highest abundance change or had a potential functional relationship with known effects of phytosterols. Annexin A2 (ANXA2) and beta-actin decrease and annexin A4 (ANXA4) and annexin A5 (ANXA5) increase were confirmed by Western blot analysis. Four of these proteins were selected for further study since they showed the highest abundance change or had a potential functional relationship with known effects of phytosterols. Annexin A2 (ANXA2) and beta-actin decrease and annexin A4 (ANXA4) and annexin A5 (ANXA5) increase were confirmed by Western blot analysis. The main results were retested in normocholesterolemic C57BL/6J mice. ANXA4 and ANXA5 protein upregulation and ANXA2 and beta-actin downregulation were reproduced in these animals. However, no changes in gene expression were found in C57BL/6J mice in either of the four proteins selected. http://www.tkuhn.ch/bel2nanopub/RA8OcOmZnzN91C0z30hQUwI1efokqRH2vEY8rsGcU7tbA#_3 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17610203 http://www.tkuhn.ch/bel2nanopub/RA8OcOmZnzN91C0z30hQUwI1efokqRH2vEY8rsGcU7tbA#_4 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA8OcOmZnzN91C0z30hQUwI1efokqRH2vEY8rsGcU7tbA#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17610203 http://www.tkuhn.ch/bel2nanopub/RA8OcOmZnzN91C0z30hQUwI1efokqRH2vEY8rsGcU7tbA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA8OcOmZnzN91C0z30hQUwI1efokqRH2vEY8rsGcU7tbA#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA8OcOmZnzN91C0z30hQUwI1efokqRH2vEY8rsGcU7tbA#_3 http://www.tkuhn.ch/bel2nanopub/RA8OcOmZnzN91C0z30hQUwI1efokqRH2vEY8rsGcU7tbA#pubinfo http://www.tkuhn.ch/bel2nanopub/RA8OcOmZnzN91C0z30hQUwI1efokqRH2vEY8rsGcU7tbA http://purl.org/dc/terms/created 2014-07-03T14:33:11.576+02:00 http://www.tkuhn.ch/bel2nanopub/RA8OcOmZnzN91C0z30hQUwI1efokqRH2vEY8rsGcU7tbA http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA8OcOmZnzN91C0z30hQUwI1efokqRH2vEY8rsGcU7tbA http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234