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Supplementary Figure 2.1. Interlinked contiguous quartet of interacting proteins (Cdh1, Agt, Rps6kb1, and Bmi1)

Supplementary Table 2.1. LC-MS/MS identification of proteins in NOD mouse pancreas

Supplementary Table 2.2. Proteins identified in the pancreas of mice

Supplementary Table 2.3. Interrogation of the protein network using specific search terms

Supplementary Table 2.4. Differentially expressed genes with a logarithmic fold change of >1 or <1, and a false discovery rate <0.05 in NIT-1 β-cells treated with FhHDM-1 as compared to untreated cells


Supplementary Table 3.1. Proteins with significantly different abundance in FhHDM-1 treated β-cells compared to untreated controls

Supplementary Table 4.1. Predicted gene targets for differentially expressed miRNAs in FhHDM-1 treated β-cells compared to untreated (Un) controls

Supplementary Table 4.2. Predicted gene targets of differentially expressed miRNAs in FhHDM-1 treated β-cells compared to untreated (Un) controls, common across all online miRNA gene target prediction tools mIRDB, DIANA and Target Scan

Supplementary Table 4.3A. List of predicted gene targets from miRNA upregulated in FhHDM-1 treated β-cells within each PANTHER DB category of molecular function and biological process (from Figure 2).

Supplementary Table 4.3B. KEGG pathway analysis of predicted gene targets from miRNA downregulated in FhHDM-1 treated β-cells compared to untreated controls

Supplementary Table 4.4. List of matched gene targets from miRNA downregulated in FhHDM-1 treated β-cells within each PANTHER DB category of molecular function and biological process (from Figure 4.5).

Supplementary Table 4.5. Differentially expressed miRNAs in FhHDM-1 treated β-cells exposed to pro-inflammatory cytokines, compared to cytokines alone

Supplementary Table 4.6. Predicted gene targets for differentially expressed miRNAs in FhHDM-1 treated β-cells exposed to pro-inflammatory cytokines compared to cytokines (CM) alone

Supplementary Table 4.7. Predicted gene targets of differentially expressed miRNAs in FhHDM-1 treated β-cells exposed to pro-inflammatory cytokines compared to cytokines (CM) alone, common across all online miRNA gene target prediction tools mIRDB, DIANA and Target Scan

Supplementary Table 4.8. KEGG pathway analysis of predicted gene targets from miRNA upregulated in FhHDM-1 treated β-cells exposed to pro-inflammatory cytokines compared to cytokines alone

Supplementary Table 4.9. KEGG pathway analysis of predicted gene targets from miRNA downregulated in FhHDM-1 treated β-cells exposed to pro-inflammatory cytokines compared to cyokines alone

Supplementary Table 4.10. Differentially expressed genes in the transcriptome of FhHDM-1 treated β-cells exposed to pro-inflammatory cytokines, compared to cytokines alone

Supplementary Table 4.11. Matched gene targets common between transcriptome and predicted gene targets of differentially expressed miRNA in FhHDM-1 treated β-cells under inflammatory conditions compared to pro-inflammatory cytokine only (CM) controls.

Supplementary Table 4.12. KEGG pathway analysis of matched genes downregulated in the transcriptome with their corresponding regulatory miRNA upregulated in FhHDM-1 β-cells exposed to pro-inflammatory cytokines compared to cytokines alone

Supplementary Table 4.13. KEGG pathway analysis of matched genes upregulated in the transcriptome with their corresponding regulatory miRNA downregulated in FhHDM-1 β-cells exposed to pro-inflammatory cytokines compared to cytokines alone
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