http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#Head http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#assertion http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#provenance http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#pubinfo http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#assertion http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#_2 http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0042789 http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=11201 http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#_3 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=10500 http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_33697 http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://purl.obolibrary.org/obo/CLO_0003684 http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#_4 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#_3 http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/directlyIncreases http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#_1 http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#assertion http://www.w3.org/2000/01/rdf-schema#label tscript(p(HGNC:SOX5)) => r(HGNC:S100B) http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#_5 http://www.w3.org/ns/prov#value To identify possible targets of the SOX trio, we carried out a microarray analysis and identified S100A1 and S100B as possible target molecules. S100 protein expression was localized in late proliferative and pre-hypertrophic chondrocytes of the mouse growth plate. Overexpression of S100A1, S100B or their combination in cultured chondrogenic cells did not induce early differentiation, but suppressed hypertrophic differentiation and mineralization. Silencing of both S100A1 and S100B stimulated terminal differentiation and reversed the SOX-trio-mediated inhibition. Finally, luciferase reporter, electrophoretic mobility shift and chromatin immunoprecipitation analyses showed that transcription of both S100 proteins is induced by the SOX trio, and also identified their respective enhancer elements in the 5'-end flanking region. http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17396138 http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17396138 http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#_5 http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw#pubinfo http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw http://purl.org/dc/terms/created 2014-07-03T14:33:09.762+02:00 http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA87MzsRFhKBIQGGVlsIYKrcBVPTwyhHrWHpnciA6f3Aw http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234