@prefix this: <http://www.tkuhn.ch/bel2nanopub/RA7qvApdOXJreV1CYr_xLbzpCjoaMWTWH1DBQkp-MBtVM> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RA7qvApdOXJreV1CYr_xLbzpCjoaMWTWH1DBQkp-MBtVM#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix schem: <http://resource.belframework.org/belframework/20131211/namespace/selventa-legacy-chemicals/> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix go: <http://amigo.geneontology.org/amigo/term/GO:> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 rdf:object go:0008219;
    rdf:predicate belv:increases;
    rdf:subject mesh:D018496;
    a rdf:Statement .
  
  sub:_2 occursIn: obo:CL_0002328, species:9606;
    rdf:object sub:_1;
    rdf:predicate belv:increases;
    rdf:subject schem:3-%284-methylphenylsulfonyl%29-2-propenenitrile;
    a rdf:Statement .
  
  sub:assertion rdfs:label "a(SCHEM:\"3-(4-methylphenylsulfonyl)-2-propenenitrile\") -> (path(MESHD:Hyperoxia) -> bp(GOBP:\"cell death\"))",
      "path(MESHD:Hyperoxia) -> bp(GOBP:\"cell death\")" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_4;
    pav:version "20131211" .
  
  sub:_3 prov:value "NHBE cells were pretreated with 0.5 to 5 ?M BAY 11-7082 before hyperoxic exposure. BAY 11-7082 is an irreversible NF-?B inhibitor that inhibits the IKK pathway to phosphorylate I?B, which is then degraded [24] and [25]. Figure 3 shows that pretreatment of NHBE cells with BAY 11-7082 accelerated hyperoxia-induced cell death. This accelerated loss of cell viability is independent of the presence of 0.5% DMSO, the vehicle for BAY 11-7082, because the extents of cell viability upon exposure to hyperoxia were similar in cells with or without 0.5% DMSO (Fig. 3). In contrast, an increase in the dose of BAY 11-7082 resulted in an incremental loss of cell viability in hyperoxia, indicating that inhibition of NF-?B can induce an accelerated, dose-dependent cell killing effect. These data suggest a protective role for NF-?B against hyperoxia-induced nonapoptotic cell death.";
    prov:wasQuotedFrom pubmed:15477018 .
  
  sub:_4 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:15477018;
    prov:wasDerivedFrom beldoc:, sub:_3 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:32:33.269+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}