@prefix this: <http://www.tkuhn.ch/bel2nanopub/RA7iLZtopvGK9ZQep0nZ7mQQQfI3FRhL4rk-AjV7U1Rwg> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RA7iLZtopvGK9ZQep0nZ7mQQQfI3FRhL4rk-AjV7U1Rwg#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix hgnc: <http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix sdis: <http://resource.belframework.org/belframework/20131211/namespace/selventa-legacy-diseases/> .
@prefix obo: <http://purl.obolibrary.org/obo/> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix mesh: <http://purl.bioontology.org/ontology/MSH/> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: hgnc:10618;
    a Protein: .
  
  sub:_2 occursIn: mesh:D003593, mesh:D013183, obo:CL_0000576, obo:UBERON_0002048, species:9606;
    rdf:object sdis:monocyte%20migration%20to%20infection;
    rdf:predicate belv:increases;
    rdf:subject sub:_1;
    a rdf:Statement .
  
  sub:assertion rdfs:label "p(HGNC:CCL2) -> path(SDIS:\"monocyte migration to infection\")" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_4;
    pav:version "20131211" .
  
  sub:_3 prov:value "Monocyte chemotactic protein-1 (MCP-1; CCL2) is a CC-chemokine that activates CCR2 on monocytes and T lymphocytes (Rose et al., 2003Go). CCR2 may play a role in COPD, as MCP-1 levels are increased in sputum, bronchoalveolar lavage, and lungs of patients with COPD (Fig. 11), and MCP-1 is expressed in alveolar macrophages, T lymphocytes, and epithelial cells (Capelli et al., 1999Go; de Boer et al., 2000Go; Traves et al., 2002Go). MCP-1 is also secreted basally by type II pneumocytes in culture, and release is stimulated by LPS but inhibited by cigarette smoke extract (Witherden et al., 2004Go). CCR2 are down-regulated via Toll-like receptors 2 and 4 and other inflammatory receptors. MCP1 is a potent chemoattractant of monocytes.";
    prov:wasQuotedFrom pubmed:15602009 .
  
  sub:_4 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:15602009;
    prov:wasDerivedFrom beldoc:, sub:_3 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:32:36.732+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}