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[Our results suggest that the higher prevalence of sporadic AD in women may be attributable to the vulnerability of female brains (especially, the hippocampus) to stressful events, which alter APP processing to favor the ?-amyloidogenesis through the transcriptional and translational upregulation of BACE1 combined with elevations in its substrate APP.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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