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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA7PdeHD7GorEkdt5Tahqg71kal-kc0cZZ7St_aZaeseo#_6 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA7PdeHD7GorEkdt5Tahqg71kal-kc0cZZ7St_aZaeseo#_5 http://www.w3.org/ns/prov#value Further study shows that OPN activated phosphoinositide 3-kinase/Akt survival pathway and up-regulated HIF-1alpha via binding to v3 integrins in gastric cancer cells. Moreover, we found that OPN could activate MMP9 and upregulate MMP2. Taken together, our results suggest that the survival-promoting function is crucial for OPN to promote the development of gastric cancer, and HIF-1 and MMP9 may play key roles during this process. http://www.tkuhn.ch/bel2nanopub/RA7PdeHD7GorEkdt5Tahqg71kal-kc0cZZ7St_aZaeseo#_5 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/19602039 http://www.tkuhn.ch/bel2nanopub/RA7PdeHD7GorEkdt5Tahqg71kal-kc0cZZ7St_aZaeseo#_6 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA7PdeHD7GorEkdt5Tahqg71kal-kc0cZZ7St_aZaeseo#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/19602039 http://www.tkuhn.ch/bel2nanopub/RA7PdeHD7GorEkdt5Tahqg71kal-kc0cZZ7St_aZaeseo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA7PdeHD7GorEkdt5Tahqg71kal-kc0cZZ7St_aZaeseo#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA7PdeHD7GorEkdt5Tahqg71kal-kc0cZZ7St_aZaeseo#_5 http://www.tkuhn.ch/bel2nanopub/RA7PdeHD7GorEkdt5Tahqg71kal-kc0cZZ7St_aZaeseo#pubinfo http://www.tkuhn.ch/bel2nanopub/RA7PdeHD7GorEkdt5Tahqg71kal-kc0cZZ7St_aZaeseo http://purl.org/dc/terms/created 2014-07-03T14:33:35.980+02:00 http://www.tkuhn.ch/bel2nanopub/RA7PdeHD7GorEkdt5Tahqg71kal-kc0cZZ7St_aZaeseo http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA7PdeHD7GorEkdt5Tahqg71kal-kc0cZZ7St_aZaeseo http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234