sub:assertion {
d:DB00575 dv:ddi-interactor-in dr:DB00575_DB00726 .
d:DB00726 dv:ddi-interactor-in dr:DB00575_DB00726 .
dr:DB00575_DB00726 dct:identifier "drugbank_resource:DB00575_DB00726" ;
dct:title "DDI between Clonidine and Trimipramine - Trimipramine may reduce the antihypertensive effect of the alpha2-agonist, Clonidine. Trimipramine may also increase the rebound hypertensive effect of Clonidine. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Clonidine if Trimipramine is initiated, discontinued or dose changed. Clonidine should be withdrawn very gradually to reduce the risk of hypertensive crisis."@en ;
a dv:Drug-Drug-Interaction ;
rdfs:label "DDI between Clonidine and Trimipramine - Trimipramine may reduce the antihypertensive effect of the alpha2-agonist, Clonidine. Trimipramine may also increase the rebound hypertensive effect of Clonidine. Consider alternate therapy or monitor for changes in the therapeutic and adverse effects of Clonidine if Trimipramine is initiated, discontinued or dose changed. Clonidine should be withdrawn very gradually to reduce the risk of hypertensive crisis. [drugbank_resource:DB00575_DB00726]"@en .
}