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[Exposure in cell culture of herpes virus to these agents results in the selection of drug-resistant variants, with resistance being due to alterations in the genes encoding the target enzymes involved in the mechanism of action of the drugs concerned, e.g. in the case of acyclovir resistance occurs as a result of deletions or alterations in the thymidine kinase (TK) or alterations in DNA polymerase genes.]. Sentence from MEDLINE/PubMed, a database of the U.S. National Library of Medicine.
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