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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA6pwh1J5j4zHP2L5lRoZmUWKdJJzFI-tsgMj8TezkCew#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA6pwh1J5j4zHP2L5lRoZmUWKdJJzFI-tsgMj8TezkCew#_6 http://www.w3.org/ns/prov#value Several kinases have been implicated in this process, including PI(3)K, Akt, glycogen synthase kinase (GSK)-3 and mammalian target of rapamycin (mTOR). Recent data indicate that obesity-induced attenuation of insulin signalling might arise from the sequential activation of protein kinase C (PKC) and inhibitor of nuclear factor-kB (IkB) kinase, although the details of this pathway have not been elucidated Knockout of PTP1B leads to increased tyrosine phosphorylation of the insulin receptor and IRS proteins in muscle and improved insulin sensitivity http://www.tkuhn.ch/bel2nanopub/RA6pwh1J5j4zHP2L5lRoZmUWKdJJzFI-tsgMj8TezkCew#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/11742412 http://www.tkuhn.ch/bel2nanopub/RA6pwh1J5j4zHP2L5lRoZmUWKdJJzFI-tsgMj8TezkCew#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA6pwh1J5j4zHP2L5lRoZmUWKdJJzFI-tsgMj8TezkCew#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/11742412 http://www.tkuhn.ch/bel2nanopub/RA6pwh1J5j4zHP2L5lRoZmUWKdJJzFI-tsgMj8TezkCew#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA6pwh1J5j4zHP2L5lRoZmUWKdJJzFI-tsgMj8TezkCew#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA6pwh1J5j4zHP2L5lRoZmUWKdJJzFI-tsgMj8TezkCew#_6 http://www.tkuhn.ch/bel2nanopub/RA6pwh1J5j4zHP2L5lRoZmUWKdJJzFI-tsgMj8TezkCew#pubinfo http://www.tkuhn.ch/bel2nanopub/RA6pwh1J5j4zHP2L5lRoZmUWKdJJzFI-tsgMj8TezkCew http://purl.org/dc/terms/created 2014-07-03T14:31:45.370+02:00 http://www.tkuhn.ch/bel2nanopub/RA6pwh1J5j4zHP2L5lRoZmUWKdJJzFI-tsgMj8TezkCew http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA6pwh1J5j4zHP2L5lRoZmUWKdJJzFI-tsgMj8TezkCew http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234