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All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA6lg7ifGSwwwAgv1BxEqeixu8dkyZuEsoXLLEpeCtvu8#_5 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA6lg7ifGSwwwAgv1BxEqeixu8dkyZuEsoXLLEpeCtvu8#_4 http://www.w3.org/ns/prov#value FoxH1 Represses Both Ligand-dependent and -independent Transactivation of the AR in LNCaP Cells—Next, we examined the possible roles of FoxH1 expression in ligand-dependent and -independent transcription of the PSA promoter induced by endogenous AR by cotransfecting LNCaP cells, the most commonly used androgen-sensitive prostate cancer cell line, with a FoxH1 expression plasmid and a PSA-luciferase reporter gene. As shown in Fig. 1B, DHT activated the AR in a concentration-dependent manner, and an ~10-fold higher induction was observed in the presence of 1 µM DHT compared with vehicle treatment. Cotransfection of the FoxH1 expression plasmid brought about a marked repression of the DHT-induced AR activation at all concentrations of DHT tested (Fig. 1B), and the repression was dose-dependent (Fig. 1C). http://www.tkuhn.ch/bel2nanopub/RA6lg7ifGSwwwAgv1BxEqeixu8dkyZuEsoXLLEpeCtvu8#_4 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/16120611 http://www.tkuhn.ch/bel2nanopub/RA6lg7ifGSwwwAgv1BxEqeixu8dkyZuEsoXLLEpeCtvu8#_5 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA6lg7ifGSwwwAgv1BxEqeixu8dkyZuEsoXLLEpeCtvu8#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/16120611 http://www.tkuhn.ch/bel2nanopub/RA6lg7ifGSwwwAgv1BxEqeixu8dkyZuEsoXLLEpeCtvu8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA6lg7ifGSwwwAgv1BxEqeixu8dkyZuEsoXLLEpeCtvu8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA6lg7ifGSwwwAgv1BxEqeixu8dkyZuEsoXLLEpeCtvu8#_4 http://www.tkuhn.ch/bel2nanopub/RA6lg7ifGSwwwAgv1BxEqeixu8dkyZuEsoXLLEpeCtvu8#pubinfo http://www.tkuhn.ch/bel2nanopub/RA6lg7ifGSwwwAgv1BxEqeixu8dkyZuEsoXLLEpeCtvu8 http://purl.org/dc/terms/created 2014-07-03T14:32:49.379+02:00 http://www.tkuhn.ch/bel2nanopub/RA6lg7ifGSwwwAgv1BxEqeixu8dkyZuEsoXLLEpeCtvu8 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA6lg7ifGSwwwAgv1BxEqeixu8dkyZuEsoXLLEpeCtvu8 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234