@prefix dcterms: .
@prefix this: .
@prefix sub: .
@prefix beldoc: .
@prefix rdfs: .
@prefix rdf: .
@prefix xsd: .
@prefix dce: .
@prefix pav: .
@prefix np: .
@prefix belv: .
@prefix prov: .
@prefix go: .
@prefix Protein: .
@prefix hgnc: .
@prefix geneProductOf: .
@prefix hasAgent: .
@prefix proteinModification: .
@prefix psimod: .
@prefix species: .
@prefix occursIn: .
@prefix obo: .
@prefix pubmed: .
@prefix orcid: .
sub:Head {
this: np:hasAssertion sub:assertion;
np:hasProvenance sub:provenance;
np:hasPublicationInfo sub:pubinfo;
a np:Nanopublication .
}
sub:assertion {
sub:_1 hasAgent: sub:_2;
a go:0016791 .
sub:_2 geneProductOf: hgnc:9644;
a Protein: .
sub:_3 belv:variantOf hgnc:6193;
a proteinModification:, psimod:00696 .
sub:_4 occursIn: obo:CL_0000169, obo:EFO_0002795, obo:UBERON_0001898, species:9606;
rdf:object sub:_3;
rdf:predicate belv:directlyDecreases;
rdf:subject sub:_1;
a rdf:Statement .
sub:assertion rdfs:label "phos(p(HGNC:PTPN11)) =| p(HGNC:JAK3,pmod(P,Y))" .
}
sub:provenance {
beldoc: dce:description "Approximately 61,000 statements.";
dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
dce:title "BEL Framework Large Corpus Document";
pav:authoredBy sub:_6;
pav:version "20131211" .
sub:_5 prov:value "SHP-2 binds to these residues on the leptin receptor via different sites [56]. Binding of SHP-2 to Y985 occurs via a SH2 domain and results in the activation of the enzyme, whereas Y974 likely associates with the active site of the enzyme SHP-2 binds to phosphotyrosine 986, becomes activated and can thus down-regulate further tyrosine phosphorylation-dependent leptin signalling such as STAT3 activation in the hypothalamus.";
prov:wasQuotedFrom pubmed:12020765 .
sub:_6 rdfs:label "Selventa" .
sub:assertion prov:hadPrimarySource pubmed:12020765;
prov:wasDerivedFrom beldoc:, sub:_5 .
}
sub:pubinfo {
this: dcterms:created "2014-07-03T14:31:49.249+02:00"^^xsd:dateTime;
pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}