. . . . . . . . . . . . "a(SCHEM:Sirolimus) =| kin(complex(NCH:\"TORC1 Complex\"))" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "1.4" . "A natural macrocyclic lactone produced by the bacterium Streptomyces hygroscopicus, with imunosuppressant properties. In cells, sirolimus binds to the immunophilin, FK Binding Protein-12 (FKBP-12) to generate an immunosuppressive complex that binds to and inhibits the activation of the mammalian Target Of Rapamycin (mTOR), a key regulatory kinase" . . "Selventa" . . . . "2014-07-03T14:30:25.832+02:00"^^ . . .