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All rights reserved. http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA5rxEXSSTHozlQ_NzsQC-ZixQgqnxOfUMrAC4yEtLVl8#_7 http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://purl.org/pav/version 1.4 http://www.tkuhn.ch/bel2nanopub/RA5rxEXSSTHozlQ_NzsQC-ZixQgqnxOfUMrAC4yEtLVl8#_6 http://www.w3.org/ns/prov#value Ppara ligands decrease cytokine-mediated Vcam1 expression through effects on Nfkb signaling. Mechanisms involved reportedly include direct Ppara interaction with p65 and Ppara dependent expression of Ikba, sequestering the inactive p65/p50 complex in the cytoplasm. % These studies provide evidence that LPL acts on LDL(-) to generate Ppara ligands, thus countering the endothelial adhesion molecule expression induced by LDL(-) alone...In contrast, LPL hydrolysis of LDL(-) limits these responses by generation PPARa ligands, increasing IkBa expression with subsequent Nfkb inhibition.% LPL-treated LDL(-) suppressed NFkB and AP-1 activation, increasing expression of the PPARa target gene IkBalpha, although only in the genetic presence of PPARa and with intact LPL hydrolysis. http://www.tkuhn.ch/bel2nanopub/RA5rxEXSSTHozlQ_NzsQC-ZixQgqnxOfUMrAC4yEtLVl8#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/12878589 http://www.tkuhn.ch/bel2nanopub/RA5rxEXSSTHozlQ_NzsQC-ZixQgqnxOfUMrAC4yEtLVl8#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA5rxEXSSTHozlQ_NzsQC-ZixQgqnxOfUMrAC4yEtLVl8#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/12878589 http://www.tkuhn.ch/bel2nanopub/RA5rxEXSSTHozlQ_NzsQC-ZixQgqnxOfUMrAC4yEtLVl8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/1.0/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA5rxEXSSTHozlQ_NzsQC-ZixQgqnxOfUMrAC4yEtLVl8#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA5rxEXSSTHozlQ_NzsQC-ZixQgqnxOfUMrAC4yEtLVl8#_6 http://www.tkuhn.ch/bel2nanopub/RA5rxEXSSTHozlQ_NzsQC-ZixQgqnxOfUMrAC4yEtLVl8#pubinfo http://www.tkuhn.ch/bel2nanopub/RA5rxEXSSTHozlQ_NzsQC-ZixQgqnxOfUMrAC4yEtLVl8 http://purl.org/dc/terms/created 2014-07-03T14:30:14.913+02:00 http://www.tkuhn.ch/bel2nanopub/RA5rxEXSSTHozlQ_NzsQC-ZixQgqnxOfUMrAC4yEtLVl8 http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA5rxEXSSTHozlQ_NzsQC-ZixQgqnxOfUMrAC4yEtLVl8 http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234