http://bio2rdf.org/drugbank:DB00575_nanopub.RA5qw71hXe3tho7adzy202bmnDOAmd8c6p08KgdPwUbfU#head http://bio2rdf.org/drugbank:DB00575_nanopub.RA5qw71hXe3tho7adzy202bmnDOAmd8c6p08KgdPwUbfU http://www.nanopub.org/nschema#hasAssertion http://bio2rdf.org/drugbank:DB00575_nanopub.RA5qw71hXe3tho7adzy202bmnDOAmd8c6p08KgdPwUbfU#assertion http://bio2rdf.org/drugbank:DB00575_nanopub.RA5qw71hXe3tho7adzy202bmnDOAmd8c6p08KgdPwUbfU http://www.nanopub.org/nschema#hasProvenance http://bio2rdf.org/drugbank:DB00575_nanopub.RA5qw71hXe3tho7adzy202bmnDOAmd8c6p08KgdPwUbfU#provenance http://bio2rdf.org/drugbank:DB00575_nanopub.RA5qw71hXe3tho7adzy202bmnDOAmd8c6p08KgdPwUbfU http://www.nanopub.org/nschema#hasPublicationInfo http://bio2rdf.org/drugbank:DB00575_nanopub.RA5qw71hXe3tho7adzy202bmnDOAmd8c6p08KgdPwUbfU#publicationInfo http://bio2rdf.org/drugbank:DB00575_nanopub.RA5qw71hXe3tho7adzy202bmnDOAmd8c6p08KgdPwUbfU http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://bio2rdf.org/drugbank:DB00575_nanopub.RA5qw71hXe3tho7adzy202bmnDOAmd8c6p08KgdPwUbfU#assertion http://bio2rdf.org/drugbank:DB00575 http://bio2rdf.org/bio2rdf_vocabulary:identifier DB00575 http://bio2rdf.org/drugbank:DB00575 http://bio2rdf.org/bio2rdf_vocabulary:namespace drugbank http://bio2rdf.org/drugbank:DB00575 http://bio2rdf.org/bio2rdf_vocabulary:uri http://bio2rdf.org/drugbank:DB00575 http://bio2rdf.org/drugbank:DB00575 http://bio2rdf.org/bio2rdf_vocabulary:x-identifiers.org http://identifiers.org/drugbank/DB00575 http://bio2rdf.org/drugbank:DB00575 http://bio2rdf.org/drugbank_vocabulary:drugbank-id APRD00174 http://bio2rdf.org/drugbank:DB00575 http://bio2rdf.org/drugbank_vocabulary:drugbank-id DB00575 http://bio2rdf.org/drugbank:DB00575 http://bio2rdf.org/drugbank_vocabulary:drugbank-id DB07566 http://bio2rdf.org/drugbank:DB00575 http://bio2rdf.org/drugbank_vocabulary:x-ahfs http://bio2rdf.org/ahfs:24:08.16 http://bio2rdf.org/drugbank:DB00575 http://bio2rdf.org/drugbank_vocabulary:x-atc http://bio2rdf.org/atc:C02AC01 http://bio2rdf.org/drugbank:DB00575 http://bio2rdf.org/drugbank_vocabulary:x-cas http://bio2rdf.org/cas:4205-90-7 http://bio2rdf.org/drugbank:DB00575 http://bio2rdf.org/drugbank_vocabulary:x-chebi http://bio2rdf.org/chebi:46631 http://bio2rdf.org/drugbank:DB00575 http://bio2rdf.org/drugbank_vocabulary:x-chemspider http://bio2rdf.org/chemspider:2701 http://bio2rdf.org/drugbank:DB00575 http://bio2rdf.org/drugbank_vocabulary:x-dpd http://bio2rdf.org/dpd:2247608 http://bio2rdf.org/drugbank:DB00575 http://bio2rdf.org/drugbank_vocabulary:x-gtp http://bio2rdf.org/gtp:516 http://bio2rdf.org/drugbank:DB00575 http://bio2rdf.org/drugbank_vocabulary:x-iuphar http://bio2rdf.org/iuphar:516 http://bio2rdf.org/drugbank:DB00575 http://bio2rdf.org/drugbank_vocabulary:x-kegg http://bio2rdf.org/kegg:D00281 http://bio2rdf.org/drugbank:DB00575 http://bio2rdf.org/drugbank_vocabulary:x-ndc http://bio2rdf.org/ndc:49884-774-86 http://bio2rdf.org/drugbank:DB00575 http://bio2rdf.org/drugbank_vocabulary:x-pdb http://bio2rdf.org/pdb:CLU http://bio2rdf.org/drugbank:DB00575 http://bio2rdf.org/drugbank_vocabulary:x-pharmgkb http://bio2rdf.org/pharmgkb:PA449051 http://bio2rdf.org/drugbank:DB00575 http://bio2rdf.org/drugbank_vocabulary:x-pubchemcompound http://bio2rdf.org/pubchem.compound:2803 http://bio2rdf.org/drugbank:DB00575 http://bio2rdf.org/drugbank_vocabulary:x-pubchemsubstance http://bio2rdf.org/pubchem.substance:46508119 http://bio2rdf.org/drugbank:DB00575 http://bio2rdf.org/drugbank_vocabulary:x-wikipedia http://bio2rdf.org/wikipedia:Clonidine http://bio2rdf.org/drugbank:DB00575 http://purl.org/dc/terms/description Clonidine, an imidazoline-derivative hypotensive agent is a centrally-acting α<sub>2</sub>-adrenergic agonist. It crosses the blood-brain barrier and acts in the hypothalamus to induce a decrease in blood pressure. It may also be administered as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone. Clonidine may be used for differential diagnosis of pheochromocytoma in hypertensive patients. Other uses for clonidine include prophylaxis of vascular migraine headaches, treatment of severe dysmenorrhea, management of vasomotor symptoms associated with menopause, rapid detoxification in the management of opiate withdrawal, treatment of alcohol withdrawal used in conjunction with benzodiazepines, management of nicotine dependence, topical use to reduce intraocular pressure in the treatment of open-angle and secondary glaucoma and hemorrhagic glaucoma associated with hypertension, and in the treatment of attention-deficit hyperactivity disorder (ADHD). Clonidine also exhibits some peripheral activity. http://bio2rdf.org/drugbank:DB00575 http://purl.org/dc/terms/identifier drugbank:DB00575 http://bio2rdf.org/drugbank:DB00575 http://purl.org/dc/terms/title Clonidine http://bio2rdf.org/drugbank:DB00575 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://bio2rdf.org/drugbank_vocabulary:Drug http://bio2rdf.org/drugbank:DB00575 http://www.w3.org/2000/01/rdf-schema#label Clonidine [drugbank:DB00575] http://bio2rdf.org/drugbank:DB00575 http://www.w3.org/2000/01/rdf-schema#seeAlso http://www.drugbank.ca/drugs/DB00575 http://bio2rdf.org/drugbank:DB00575 http://www.w3.org/2000/01/rdf-schema#seeAlso http://www.drugs.com/clonidine.html http://bio2rdf.org/drugbank:DB00575 http://www.w3.org/2000/01/rdf-schema#seeAlso http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/cat1072.shtml http://bio2rdf.org/drugbank:DB00575 http://www.w3.org/2000/01/rdf-schema#seeAlso http://www.rxlist.com/cgi/generic/clonidin.htm http://bio2rdf.org/drugbank:DB00575_nanopub.RA5qw71hXe3tho7adzy202bmnDOAmd8c6p08KgdPwUbfU#provenance http://bio2rdf.org/drugbank:DB00575_nanopub.RA5qw71hXe3tho7adzy202bmnDOAmd8c6p08KgdPwUbfU#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://bio2rdf.org/drugbank_resource:bio2rdf.dataset.drugbank.R3 http://www.w3.org/ns/dcat#distribution http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://purl.org/dc/terms/created 2015-01-09T17:00:50-05:00 http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz http://www.w3.org/ns/prov#wasDerivedFrom http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00 http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00 http://purl.org/pav/retrievedOn 2014-11-12T07:57:03-05:00 http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00 http://www.w3.org/ns/prov#wasDerivedFrom http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip http://www.w3.org/ns/prov#wasAttributedTo http://drugbank.ca http://bio2rdf.org/drugbank:DB00575_nanopub.RA5qw71hXe3tho7adzy202bmnDOAmd8c6p08KgdPwUbfU#publicationInfo http://bio2rdf.org/drugbank:DB00575_nanopub.RA5qw71hXe3tho7adzy202bmnDOAmd8c6p08KgdPwUbfU#signature.MC0CFQCTCXfONziw http://purl.org/nanopub/x/hasPublicKey MIIBtzCCASwGByqGSM44BAEwggEfAoGBAP1/U4EddRIpUt9KnC7s5Of2EbdSPO9EAMMeP4C2USZpRV1AIlH7WT2NWPq/xfW6MPbLm1Vs14E7gB00b/JmYLdrmVClpJ+f6AR7ECLCT7up1/63xhv4O1fnxqimFQ8E+4P208UewwI1VBNaFpEy9nXzrith1yrv8iIDGZ3RSAHHAhUAl2BQjxUjC8yykrmCouuEC/BYHPUCgYEA9+GghdabPd7LvKtcNrhXuXmUr7v6OuqC+VdMCz0HgmdRWVeOutRZT+ZxBxCBgLRJFnEj6EwoFhO3zwkyjMim4TwWeotUfI0o4KOuHiuzpnWRbqN/C/ohNWLx+2J6ASQ7zKTxvqhRkImog9/hWuWfBpKLZl6Ae1UlZAFMO/7PSSoDgYQAAoGAETGrDm8R3KfndKRj7ttr3jVhhstI6/2Ey0ER9F5kdx7Hrd6eolq7yWzPzf2H754tdZxICzxYcdawBbL2ZUzFjWwXTNUQC3+e6evKPJyNELubnZcA+8TxIIwicBnw3Ku6mSeI8SUVr5SBV1VeJoSu/ahldv562IdBR8IagmzuT3Y= http://bio2rdf.org/drugbank:DB00575_nanopub.RA5qw71hXe3tho7adzy202bmnDOAmd8c6p08KgdPwUbfU#signature.MC0CFQCTCXfONziw http://purl.org/nanopub/x/hasSignature MC0CFQCTCXfONziwC9tld35QR18lt/1kZgIUW6Q2xHMTyCXa2xZyB4me0W6mqVw= http://bio2rdf.org/drugbank:DB00575_nanopub.RA5qw71hXe3tho7adzy202bmnDOAmd8c6p08KgdPwUbfU#signature.MC0CFQCTCXfONziw http://purl.org/nanopub/x/signedBy https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://bio2rdf.org/drugbank:DB00575_nanopub.RA5qw71hXe3tho7adzy202bmnDOAmd8c6p08KgdPwUbfU http://purl.org/dc/terms/created 2018-03-30T11:11:12.062+02:00 http://bio2rdf.org/drugbank:DB00575_nanopub.RA5qw71hXe3tho7adzy202bmnDOAmd8c6p08KgdPwUbfU http://purl.org/dc/terms/license https://creativecommons.org/licenses/by-nc/4.0/ http://bio2rdf.org/drugbank:DB00575_nanopub.RA5qw71hXe3tho7adzy202bmnDOAmd8c6p08KgdPwUbfU http://purl.org/nanopub/x/hasSignatureElement http://bio2rdf.org/drugbank:DB00575_nanopub.RA5qw71hXe3tho7adzy202bmnDOAmd8c6p08KgdPwUbfU#signature.MC0CFQCTCXfONziw http://bio2rdf.org/drugbank:DB00575_nanopub.RA5qw71hXe3tho7adzy202bmnDOAmd8c6p08KgdPwUbfU http://www.w3.org/ns/prov#wasGeneratedBy https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://www.w3.org/ns/prov#specializationOf https://github.com/tkuhn/bio2rdf2nanopub https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB http://www.w3.org/ns/prov#wasAttributedTo http://orcid.org/0000-0002-1267-0234 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://purl.org/dc/terms/identifier 7720f136-841b-4851-a6e4-ad20a409a475 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://www.w3.org/ns/prov#used https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://www.w3.org/ns/prov#wasAssociatedWith https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475 http://www.w3.org/ns/prov#wasStartedBy http://orcid.org/0000-0002-1267-0234 https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://purl.org/dc/terms/isVersionOf https://github.com/tkuhn/bio2rdf2nanopub https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://purl.org/pav/version eda7951a5f6c622c5d2132f50c3093138484a349 https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349 http://www.w3.org/ns/prov#wasAttributedTo http://orcid.org/0000-0002-1267-0234