@prefix this: <http://bio2rdf.org/drugbank:DB00575_nanopub.RA5qw71hXe3tho7adzy202bmnDOAmd8c6p08KgdPwUbfU> .
@prefix sub: <http://bio2rdf.org/drugbank:DB00575_nanopub.RA5qw71hXe3tho7adzy202bmnDOAmd8c6p08KgdPwUbfU#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix pav: <http://purl.org/pav/> .
@prefix orcid: <http://orcid.org/> .
@prefix codebase: <https://github.com/tkuhn/bio2rdf2nanopub> .
@prefix version: <https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349> .
@prefix instance: <https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB> .
@prefix process: <https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix v: <http://bio2rdf.org/bio2rdf_vocabulary:> .
@prefix d: <http://bio2rdf.org/drugbank:> .
@prefix dv: <http://bio2rdf.org/drugbank_vocabulary:> .
@prefix dr: <http://bio2rdf.org/drugbank_resource:> .
@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix npx: <http://purl.org/nanopub/x/> .
sub:head {
   this: np:hasAssertion sub:assertion ;
    np:hasProvenance sub:provenance ;
    np:hasPublicationInfo sub:publicationInfo ;
    a np:Nanopublication .
}
sub:assertion {
   d:DB00575 v:identifier "DB00575" ;
    v:namespace "drugbank" ;
    v:uri "http://bio2rdf.org/drugbank:DB00575" ;
    v:x-identifiers.org <http://identifiers.org/drugbank/DB00575> ;
    dv:drugbank-id "APRD00174" , "DB00575" , "DB07566" ;
    dv:x-ahfs <http://bio2rdf.org/ahfs:24:08.16> ;
    dv:x-atc <http://bio2rdf.org/atc:C02AC01> ;
    dv:x-cas <http://bio2rdf.org/cas:4205-90-7> ;
    dv:x-chebi <http://bio2rdf.org/chebi:46631> ;
    dv:x-chemspider <http://bio2rdf.org/chemspider:2701> ;
    dv:x-dpd <http://bio2rdf.org/dpd:2247608> ;
    dv:x-gtp <http://bio2rdf.org/gtp:516> ;
    dv:x-iuphar <http://bio2rdf.org/iuphar:516> ;
    dv:x-kegg <http://bio2rdf.org/kegg:D00281> ;
    dv:x-ndc <http://bio2rdf.org/ndc:49884-774-86> ;
    dv:x-pdb <http://bio2rdf.org/pdb:CLU> ;
    dv:x-pharmgkb <http://bio2rdf.org/pharmgkb:PA449051> ;
    dv:x-pubchemcompound <http://bio2rdf.org/pubchem.compound:2803> ;
    dv:x-pubchemsubstance <http://bio2rdf.org/pubchem.substance:46508119> ;
    dv:x-wikipedia <http://bio2rdf.org/wikipedia:Clonidine> ;
    dct:description "Clonidine, an imidazoline-derivative hypotensive agent is a centrally-acting &alpha;<sub>2</sub>-adrenergic agonist. It crosses the blood-brain barrier and acts in the hypothalamus to induce a decrease in blood pressure. It may also be administered as an epidural infusion as an adjunct treatment in the management of severe cancer pain that is not relieved by opiate analgesics alone. Clonidine may be used for differential diagnosis of pheochromocytoma in hypertensive patients. Other uses for clonidine include prophylaxis of vascular migraine headaches, treatment of severe dysmenorrhea, management of vasomotor symptoms associated with menopause, rapid detoxification in the management of opiate withdrawal, treatment of alcohol withdrawal used in conjunction with benzodiazepines, management of nicotine dependence, topical use to reduce intraocular pressure in the treatment of open-angle and secondary glaucoma and hemorrhagic glaucoma associated with hypertension, and in the treatment of attention-deficit hyperactivity disorder (ADHD). Clonidine also exhibits some peripheral activity."@en ;
    dct:identifier "drugbank:DB00575" ;
    dct:title "Clonidine"@en ;
    a dv:Drug ;
    rdfs:label "Clonidine [drugbank:DB00575]"@en ;
    rdfs:seeAlso <http://www.drugbank.ca/drugs/DB00575> , <http://www.drugs.com/clonidine.html> , <http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/cat1072.shtml> , <http://www.rxlist.com/cgi/generic/clonidin.htm> .
}
sub:provenance {
   sub:assertion prov:wasDerivedFrom <http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz> .
  dr:bio2rdf.dataset.drugbank.R3 dcat:distribution <http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz> .
  <http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz> dct:created "2015-01-09T17:00:50-05:00"^^xsd:dateTime ;
    prov:wasDerivedFrom <http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00> .
  <http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00> pav:retrievedOn "2014-11-12T07:57:03-05:00"^^xsd:dateTime ;
    prov:wasDerivedFrom <http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip> .
  <http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip> prov:wasAttributedTo <http://drugbank.ca> .
}
sub:publicationInfo {
   sub:signature.MC0CFQCTCXfONziw npx:hasPublicKey "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" ;
    npx:hasSignature "MC0CFQCTCXfONziwC9tld35QR18lt/1kZgIUW6Q2xHMTyCXa2xZyB4me0W6mqVw=" ;
    npx:signedBy instance: .
  this: dct:created "2018-03-30T11:11:12.062+02:00"^^xsd:dateTime ;
    dct:license <https://creativecommons.org/licenses/by-nc/4.0/> ;
    npx:hasSignatureElement sub:signature.MC0CFQCTCXfONziw ;
    prov:wasGeneratedBy process: .
  instance: prov:specializationOf codebase: ;
    prov:wasAttributedTo orcid:0000-0002-1267-0234 .
  process: dct:identifier "7720f136-841b-4851-a6e4-ad20a409a475" ;
    prov:used version: ;
    prov:wasAssociatedWith instance: ;
    prov:wasStartedBy orcid:0000-0002-1267-0234 .
  version: dct:isVersionOf codebase: ;
    pav:version "eda7951a5f6c622c5d2132f50c3093138484a349" ;
    prov:wasAttributedTo orcid:0000-0002-1267-0234 .
}