@prefix this: <http://bio2rdf.org/drugbank:DB01109_nanopub.RA5pIOv0MBuh1Q3Omy1uiEzQEfdGkUmKPz2EgTS6M2KdA> .
@prefix sub: <http://bio2rdf.org/drugbank:DB01109_nanopub.RA5pIOv0MBuh1Q3Omy1uiEzQEfdGkUmKPz2EgTS6M2KdA#> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix pav: <http://purl.org/pav/> .
@prefix orcid: <http://orcid.org/> .
@prefix codebase: <https://github.com/tkuhn/bio2rdf2nanopub> .
@prefix version: <https://github.com/tkuhn/bio2rdf2nanopub/tree/eda7951a5f6c622c5d2132f50c3093138484a349> .
@prefix instance: <https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB> .
@prefix process: <https://github.com/tkuhn/bio2rdf2nanopub#instance.MIIBtzCCASwGByqGSM44BAEwggEfAoGB.7720f136-841b-4851-a6e4-ad20a409a475> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix v: <http://bio2rdf.org/bio2rdf_vocabulary:> .
@prefix d: <http://bio2rdf.org/drugbank:> .
@prefix dv: <http://bio2rdf.org/drugbank_vocabulary:> .
@prefix dr: <http://bio2rdf.org/drugbank_resource:> .
@prefix dcat: <http://www.w3.org/ns/dcat#> .
@prefix npx: <http://purl.org/nanopub/x/> .

sub:head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:publicationInfo;
    a np:Nanopublication .
}

sub:assertion {
  d:DB01109 v:identifier "DB01109";
    v:namespace "drugbank";
    v:uri "http://bio2rdf.org/drugbank:DB01109";
    v:x-identifiers.org <http://identifiers.org/drugbank/DB01109>;
    dv:drugbank-id "APRD00056", "DB01109";
    dv:x-ahfs <http://bio2rdf.org/ahfs:20:12.04.16>;
    dv:x-atc <http://bio2rdf.org/atc:C05BA01>;
    dv:x-cas <http://bio2rdf.org/cas:9005-49-6>;
    dv:x-chebi <http://bio2rdf.org/chebi:28304>;
    dv:x-chemspider <http://bio2rdf.org/chemspider:751>;
    dv:x-dpd <http://bio2rdf.org/dpd:453781>;
    dv:x-kegg <http://bio2rdf.org/kegg:C00374>;
    dv:x-ndc <http://bio2rdf.org/ndc:0009-0268-01>;
    dv:x-pharmgkb <http://bio2rdf.org/pharmgkb:PA449855>;
    dv:x-pubchemsubstance <http://bio2rdf.org/pubchem.substance:46507594>;
    dv:x-wikipedia <http://bio2rdf.org/wikipedia:Heparin>;
    dct:description "Unfractionated heparin (UH) is a heterogenous preparation of anionic, sulfated glycosaminoglycan polymers with weights ranging from 3000 to 30,000 Da. It is a naturally occurring anticoagulant released from mast cells. It binds reversibly to antithrombin III (ATIII) and greatly accelerates the rate at which ATIII inactivates coagulation enzymes thrombin (factor IIa) and factor Xa. UH is different from low molecular weight heparin (LMWH) in the following ways: the average molecular weight of LMWH is about 4.5 kDa whereas it is 15 kDa for UH; UH requires continuous infusions; activated partial prothrombin time (aPTT) monitoring is required when using UH; and UH has a higher risk of bleeding and higher risk of osteoporosis in long term use. Unfractionated heparin is more specific than LMWH for thrombin. Furthermore, the effects of UH can typically be reversed by using protamine sulfate."@en;
    dct:identifier "drugbank:DB01109";
    dct:title "Heparin"@en;
    a dv:Drug;
    rdfs:label "Heparin [drugbank:DB01109]"@en;
    rdfs:seeAlso <http://www.drugbank.ca/drugs/DB01109>, <http://www.drugs.com/heparin.html>,
      <http://www.rxlist.com/cgi/generic/heparin.htm> .
}

sub:provenance {
  sub:assertion prov:wasDerivedFrom <http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz> .
  
  dr:bio2rdf.dataset.drugbank.R3 dcat:distribution <http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz> .
  
  <http://download.bio2rdf.org/release/3/drugbank/drugbank.nq.gz> dct:created "2015-01-09T17:00:50-05:00"^^xsd:dateTime;
    prov:wasDerivedFrom <http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00> .
  
  <http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip#retrieved-on:2014-11-12T07:57:03-05:00>
    pav:retrievedOn "2014-11-12T07:57:03-05:00"^^xsd:dateTime;
    prov:wasDerivedFrom <http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip> .
  
  <http://www.drugbank.ca/system/downloads/current/drugbank.xml.zip> prov:wasAttributedTo
      <http://drugbank.ca> .
}

sub:publicationInfo {
  sub:signature.MC0CFQCK4ttHGOrP npx:hasPublicKey "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";
    npx:hasSignature "MC0CFQCK4ttHGOrPo2vwQAIBa0K0EIpKhgIUeN991X1bJxfue/FmnwlMauWipq4=";
    npx:signedBy instance: .
  
  this: dct:created "2018-03-30T11:11:07.010+02:00"^^xsd:dateTime;
    dct:license <https://creativecommons.org/licenses/by-nc/4.0/>;
    npx:hasSignatureElement sub:signature.MC0CFQCK4ttHGOrP;
    prov:wasGeneratedBy process: .
  
  instance: prov:specializationOf codebase:;
    prov:wasAttributedTo orcid:0000-0002-1267-0234 .
  
  process: dct:identifier "7720f136-841b-4851-a6e4-ad20a409a475";
    prov:used version:;
    prov:wasAssociatedWith instance:;
    prov:wasStartedBy orcid:0000-0002-1267-0234 .
  
  version: dct:isVersionOf codebase:;
    pav:version "eda7951a5f6c622c5d2132f50c3093138484a349";
    prov:wasAttributedTo orcid:0000-0002-1267-0234 .
}