http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#Head http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE http://www.nanopub.org/nschema#hasAssertion http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#assertion http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE http://www.nanopub.org/nschema#hasProvenance http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#provenance http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE http://www.nanopub.org/nschema#hasPublicationInfo http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#pubinfo http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.nanopub.org/nschema#Nanopublication http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#assertion http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#_1 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#_2 http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#_1 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0042789 http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#_2 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=11631 http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#_2 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#_3 http://semanticscience.org/resource/SIO_000139 http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#_4 http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#_3 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://amigo.geneontology.org/amigo/term/GO:0042789 http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#_4 http://purl.obolibrary.org/obo/RO_0002204 http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=3488 http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#_4 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080 http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#_5 http://purl.obolibrary.org/obo/BFO_0000066 http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=9606 http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#object http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#_3 http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#predicate http://www.selventa.com/vocabulary/increases http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#subject http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#_1 http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#_5 http://www.w3.org/1999/02/22-rdf-syntax-ns#type http://www.w3.org/1999/02/22-rdf-syntax-ns#Statement http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#assertion http://www.w3.org/2000/01/rdf-schema#label tscript(p(HGNC:TCF20)) -> tscript(p(HGNC:ETS1)) http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#provenance http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/description Approximately 61,000 statements. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/rights Copyright (c) 2011-2012, Selventa. All rights reserved. http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/dc/elements/1.1/title BEL Framework Large Corpus Document http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/authoredBy http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#_7 http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://purl.org/pav/version 20131211 http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#_6 http://www.w3.org/ns/prov#value Both SPBP and TopBP1 enhanced the transcriptional activity of Ets1 on the c-myc P1P2- and matrix metalloproteinase-3 (MMP3) promoters. Together they displayed a more than additive effect. Both proteins were associated with these promoters. The involvement of TopBP1 was dependent on the serine 1159 phosphorylation site, known to be important for transcriptional activation. Depletion of endogenous SPBP by siRNA treatment reduced MMP3 secretion by 50% in phorbol ester-stimulated human fibroblasts. Taken together, our results show that TopBP1 and SPBP interact physically and functionally to co-operate as co-activators of Ets1. http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#_6 http://www.w3.org/ns/prov#wasQuotedFrom http://www.ncbi.nlm.nih.gov/pubmed/17913746 http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#_7 http://www.w3.org/2000/01/rdf-schema#label Selventa http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#assertion http://www.w3.org/ns/prov#hadPrimarySource http://www.ncbi.nlm.nih.gov/pubmed/17913746 http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#assertion http://www.w3.org/ns/prov#wasDerivedFrom http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#_6 http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE#pubinfo http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE http://purl.org/dc/terms/created 2014-07-03T14:33:12.983+02:00 http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE http://purl.org/pav/createdBy http://orcid.org/0000-0001-6818-334X http://www.tkuhn.ch/bel2nanopub/RA5h_a8pnZQXLzVC3TvSUGQFFoaoQSCcaOOGdMCHmzjpE http://purl.org/pav/createdBy http://orcid.org/0000-0002-1267-0234