@prefix this: <http://www.tkuhn.ch/bel2nanopub/RA5V7hQE4e7ntYvvx-dLS0Y-THVssnL9Znoz5EzbgxJxw> .
@prefix sub: <http://www.tkuhn.ch/bel2nanopub/RA5V7hQE4e7ntYvvx-dLS0Y-THVssnL9Znoz5EzbgxJxw#> .
@prefix beldoc: <http://resource.belframework.org/belframework/20131211/knowledge/large_corpus.bel> .
@prefix rdfs: <http://www.w3.org/2000/01/rdf-schema#> .
@prefix rdf: <http://www.w3.org/1999/02/22-rdf-syntax-ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .
@prefix dct: <http://purl.org/dc/terms/> .
@prefix dce: <http://purl.org/dc/elements/1.1/> .
@prefix pav: <http://purl.org/pav/> .
@prefix np: <http://www.nanopub.org/nschema#> .
@prefix belv: <http://www.selventa.com/vocabulary/> .
@prefix prov: <http://www.w3.org/ns/prov#> .
@prefix chebi: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=> .
@prefix Protein: <http://www.ebi.ac.uk/chebi/searchId.do?chebiId=CHEBI_36080> .
@prefix mgi: <http://www.informatics.jax.org/marker/MGI:> .
@prefix geneProductOf: <http://purl.obolibrary.org/obo/RO_0002204> .
@prefix species: <http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?id=> .
@prefix occursIn: <http://purl.obolibrary.org/obo/BFO_0000066> .
@prefix pubmed: <http://www.ncbi.nlm.nih.gov/pubmed/> .
@prefix orcid: <http://orcid.org/> .

sub:Head {
  this: np:hasAssertion sub:assertion;
    np:hasProvenance sub:provenance;
    np:hasPublicationInfo sub:pubinfo;
    a np:Nanopublication .
}

sub:assertion {
  sub:_1 geneProductOf: mgi:98259;
    a Protein: .
  
  sub:_2 occursIn: species:10090;
    rdf:object sub:_1;
    rdf:predicate belv:increases;
    rdf:subject chebi:5931;
    a rdf:Statement .
  
  sub:assertion rdfs:label "a(CHEBI:\"insulin (human)\") -> p(MGI:Ccl2)" .
}

sub:provenance {
  beldoc: dce:description "Approximately 61,000 statements.";
    dce:rights "Copyright (c) 2011-2012, Selventa. All rights reserved.";
    dce:title "BEL Framework Large Corpus Document";
    pav:authoredBy sub:_4;
    pav:version "20131211" .
  
  sub:_3 prov:value "Insulin treatment of insulin resistant adipocytes led to an increase in the mRNA levels of CCL2 from 1.0 to 9.5. And treatment of adipocytes for 3 hours with 1000 nM insulin invitro led to a 10-fold induction in MCP1 mRNA levels, regardless of insulin resistance offered by the cell. Insulin treatment also led to an increase in MCP1 secretion from both normal and insulin resistant adipocytes. Upregulation of MCP-1 gene expression (4 folds) in response to insulin was also observed in in-vivo studies which made use of female obese mice (ob/ob).";
    prov:wasQuotedFrom pubmed:12756299 .
  
  sub:_4 rdfs:label "Selventa" .
  
  sub:assertion prov:hadPrimarySource pubmed:12756299;
    prov:wasDerivedFrom beldoc:, sub:_3 .
}

sub:pubinfo {
  this: dct:created "2014-07-03T14:32:02.259+02:00"^^xsd:dateTime;
    pav:createdBy orcid:0000-0001-6818-334X, orcid:0000-0002-1267-0234 .
}