. . . . . . . . . . "a(CHEBI:\"hydrogen peroxide\") -> a(CHEBI:\"reactive oxygen species\")" . "Approximately 61,000 statements." . "Copyright (c) 2011-2012, Selventa. All rights reserved." . "BEL Framework Large Corpus Document" . . "20131211" . "It is well known that addition of H2O2 can cause oxidative stress and cell death since it easily permeates through the membranes. For the same reason, H2O2 added to a cell culture is quickly decomposed due to activity of catalase and other cellular H2O2-consuming systems. For example, we found that 20 ?M H2O2 added to a culture of HeLa cells was completely decomposed in 15?20 min [19]. On the other hand, significant accumulation of ROS in the H2O2-treated cells was detected 45 min after addition of peroxide (Fig. 7), indicating activation of endogenous ROS production by added H2O2. " . . "Selventa" . . . . "2014-07-03T14:33:00.269+02:00"^^ . . .